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Nucleic acid medicine and application thereof

A nucleic acid drug and pharmaceutical technology, applied in the field of biomedicine, to achieve the effect of strong specificity and high safety

Pending Publication Date: 2022-03-22
川北医学院附属医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, the current RNA drugs are mainly based on local diseases such as macular degeneration and hepatitis, and rare diseases like Huntington's disease, while the research on RNA drugs for osteoporosis is still rare due to the problems of targeting and delivery methods to report

Method used

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  • Nucleic acid medicine and application thereof
  • Nucleic acid medicine and application thereof
  • Nucleic acid medicine and application thereof

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Experimental program
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Embodiment

[0029] The experimental steps and specific parameters involved in this embodiment, if there are no special restrictions or specific instructions, can refer to the routine experimental steps and parameters in this field; at the same time, if there are no special restrictions or specific instructions, the specific reagents used can be purchased directly. product.

[0030] 1. Mechanical unloading conditions inhibit the expression level of AK018451

[0031] Construct RPM (random positioning machine, three-dimensional random rotation, which means that cells are cultured under the condition of random rotation in different directions and speeds, so as to simulate the mechanical unloading environment for cells) in vitro mechanical unloading model, and HLU (Hind Limb Unloading, hind limb Tail suspension refers to raising the tail of experimental mice so that the hind limbs of the mice are unloaded because they do not touch the ground) In vivo mechanical unloading model, detection of AK...

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Abstract

The invention discloses a nucleic acid drug and application thereof, and belongs to the technical field of biomedicine, the nucleic acid drug is derived from an RNA sequence of mouse-derived long-chain non-coding RNA AK018451, and it is found that the sequence can play a role in inhibiting osteoporosis, so that a part of the sequence of a functional area of the sequence is used as the nucleic acid drug and is named as DORA. Meanwhile, the DORA sequence based on the AK018451 sequence can achieve a treatment effect on osteoporosis by targeting PIEZO1, can be used as an RNA drug, has the characteristics of high specificity and high safety compared with other osteoporosis treatment drugs, and has a huge potential application value in treatment and / or prevention of disuse osteoporosis.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a nucleic acid drug and its application. Background technique [0002] Disuse osteoporosis is a disease in which the mechanical stimulation of bones is reduced or absent, resulting in loss of bone mass and osteoporosis symptoms. 73.3% of long-term bedridden patients suffer from osteoporosis due to lack of exercise, and the bone mineral density of the hip and lumbar spine of the patients decreased significantly. In addition, long-term immobilization, medium and long-term space flight (weightless environment), and reduced exercise caused by aging will all lead to a decrease in the rate of bone formation and an increase in the rate of bone resorption, eventually causing disuse osteoporosis. my country is currently in the process of accelerating population aging, and disuse osteoporosis will become one of the major threats to the health of the elderly in my country in the future...

Claims

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Application Information

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IPC IPC(8): C12N15/113A61K31/7105A61P19/10
CPCC12N15/113A61K31/7105A61P19/10C12N2320/30
Inventor 印崇侯忆梅邓萌郭晓兰陈志浩
Owner 川北医学院附属医院