3D printing pharmaceutical method with controllable release time
A technology of release time and 3D printing, which is applied in the direction of making drugs into special physical or ingestible devices, processing and manufacturing, manufacturing auxiliary devices, etc., which can solve the problems of high cost, reduced workload and production cost, and large drug workload. And other issues
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Embodiment 1
[0033] Such as figure 1 Shown is an embodiment of a 3D printing pharmaceutical method with controllable release time, including the following steps:
[0034] Step 1: Input the original model of different drugs into the printer. The original model of the drug includes the medicinal material and the excipient layer that wraps the medicinal material; extract the data of the excipient layer in the original model of the drug, and the excipient layer corresponds to the fixed release time of the drug, and establishes The standard release time T of the auxiliary material layer;
[0035]Step 2: Set the target release time T1 of the drug X, select the excipient layer with the standard release time T of the excipient layer closest to T1, and the gap between the fixed drug release time T and the target release time T1 is △T1=T-T1; if △ T1 is greater than zero, a number of pores with a volume of S are generated in the auxiliary material layer, each pore corresponds to a reduction in relea...
Embodiment 2
[0039] Example 2 of a 3D printing pharmaceutical method with controllable release time, based on Example 1, on the basis of Example 1, the target release time of drug X is set as T2, T2 is inconsistent with T1, and drug model 1 is used as Basic Generative Drug Model II. For the target release time T2 of the drug model 2, if T2 is less than T1 and T1 is less than T, execute setting 1; if T2 is greater than T1 and less than T, execute setting 2;
[0040] Setting 1: Based on the auxiliary material layer of the new model 1 generated in step 2; print 1 unit of immediate-release control agent in the pores, and each unit of immediate-release control agent corresponds to a reduction in release time t3, printing of the immediate-release control agent The amount is n2=(T1-T2) / t3;
[0041] Setting 2: Based on the excipient layer of the new model 1 generated in step 2; print 1 unit of slow-release control agent in the pores, and each unit of slow-release control agent corresponds to an i...
Embodiment 3
[0045] Example 3 of a 3D printing pharmaceutical method with controllable release time, based on Example 2, on the basis of Example 2, according to step 2, three layers of sequentially nested excipient layers with increasing release time are generated, and the drug X is distributed in the cavity between each excipient layer, generating a multi-layer nested drug model three. Wherein the release of the auxiliary material layer located in the middle position wherein the release time of the auxiliary material layer located in the middle position is set as the target release time T0, and the release time of the auxiliary material layer located in the outer layer is set to be shorter than the target release time T0-L, The release time of the auxiliary material layer located in the inner layer is set to be longer than the target release time T0+L. The drug located between each excipient layer can be released intermittently, and the release time of the drug will be within the range of...
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