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Research method and application of benzbromarone in treatment of acute myelogenous leukemia

A benzbromarone, acute myeloid technology, applied in biochemical equipment and methods, pharmaceutical formulations, compound screening, etc., can solve the problems of difficult to obtain specific inhibitors, difficult to clinical transformation, etc., achieve growth inhibition, induction effect of apoptosis

Pending Publication Date: 2022-04-19
GANNAN MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In recent years, a variety of phosphatases, including PP2A, have been found to play a key role in the occurrence and development of AML, and can be targeted for targeted therapy, but it is difficult to translate into the clinic because it is difficult to obtain specific inhibitors

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  • Research method and application of benzbromarone in treatment of acute myelogenous leukemia
  • Research method and application of benzbromarone in treatment of acute myelogenous leukemia
  • Research method and application of benzbromarone in treatment of acute myelogenous leukemia

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Embodiment Construction

[0028] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments It is a part of embodiments of the present invention, but not all embodiments. The components of the embodiments of the invention generally described and illustrated in the figures herein may be arranged and designed in a variety of different configurations.

[0029] Accordingly, the following detailed description of the embodiments of the invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely represents selected embodiments of the invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art wi...

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Abstract

The invention discloses a research method and application of benzbromarone in treatment of acute myeloid leukemia, benzbromarone is used as an inhibitor of EYA phosphatase, can effectively inhibit growth of leukemia cell strains, can also effectively inhibit self-renewal capacity of the leukemia cell strains and promote differentiation of the leukemia cell strains, and has a good application prospect in treatment of acute myeloid leukemia. And apoptosis is induced by disturbing the cell cycle of leukemia cells.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a research method and application of benzbromarone for treating acute myeloid leukemia. Background technique [0002] Leukemia is a cancer originating in the bone marrow. It is characterized by abnormal proliferation of white blood cells and inhibition of production of functional blood cells. It is a malignant tumor with poor prognosis and high mortality. Common leukemias can be divided into four different types: acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL) and chronic myeloid leukemia (CML). In China, the annual incidence and mortality of leukemia are 5.3 / 100,000 and 3.3 / 100,000, respectively, ranking among the top ten relative incidence rates in the world. Among various leukemia subtypes, the incidence of AML is extremely high and is increasing year by year. More than half of the patients who die from leuke...

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Application Information

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IPC IPC(8): C12Q1/02A61K31/343A61P35/02
CPCG01N33/5011A61K31/343A61P35/02C12N2503/02G01N2500/10
Inventor 甘滔张翔王烈峰张峰华耿戈戈丁超熊梦婕
Owner GANNAN MEDICAL UNIV