Phage vaginal suppository for livestock and preparation method thereof

Abstract

The invention discloses a bacteriophage vaginal suppository for livestock and a preparation method of the bacteriophage vaginal suppository. The bacteriophage vaginal suppository comprises the following raw material components: 150-300 parts of a matrix, 60-120 parts of bacteriophage, 50-100 parts of a cosolvent, 15-30 parts of a poisoning agent, 15-30 parts of a beneficial absorption agent, 10-20 parts of an insect repellant and 5-10 parts of a preservative. The bacteriophage vaginal suppository has the beneficial effects that the bacteriophage vaginal suppository for the livestock can effectively inhibit germs in vagina of the livestock, and does not generate drug resistance; through the design of the poison killing agent, endotoxin in the vagina can be removed, the body temperature of livestock is prevented from rising, vaccine failure is further avoided, and economic losses are reduced.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations for animal health, in particular to a bacteriophage vaginal suppository for livestock and a preparation method thereof. Background technique [0002] Vaginitis in domestic animals is a common and multiple reproductive organ disease in production. The main causes of its occurrence are postpartum vaginal injury, artificial insemination, lax disinfection, vaginal injury of sows during natural mating, and infection by pathogenic microorganisms through various channels. And cause vaginitis, need to use vaginal suppository to treat. [0003] The field of existing livestock vaginal suppositories, such as Chinese Patent No. CN102512358A, discloses a rifaximin vaginal suppository for livestock and a preparation method thereof, which includes a solid dispersion of rifaximin, a matrix, a surfactant, a synergist, an antiseptic agent, etc., so as to ensure the uniform dispersion of the mai...

AI Technical Summary

Problems solved by technology

However, after long-term use of rifaximin, it is easy to produce drug resistance, and in domestic animals, such as vaginal infection of Escherichia coli in domestic pigs, the body temperature of domestic pigs will not go back. Immunization failure, a large number of domestic pigs died, resulting in economic losses

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