Phage vaginal suppository for livestock and preparation method thereof

The technology of vaginal suppository and bacteriophage, which is applied to the field of phage vaginal suppository for livestock and its preparation, can solve the problems of easy generation of drug resistance, economic loss, death of domestic pigs, etc., so as to avoid the rise of body temperature, reduce economic loss and improve drug efficacy. Effect

Pending Publication Date: 2022-05-13
PHAGELUX (NANJING) BIO-TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after long-term use of rifaximin, it is easy to produce drug resistance, and in domestic animals, such as vaginal infection of Escherichia coli in do

Method used

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  • Phage vaginal suppository for livestock and preparation method thereof
  • Phage vaginal suppository for livestock and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] A bacteriophage vaginal suppository for livestock, which is made of the following raw materials:

[0044] 150g of substrate, 60g of bacteriophage, 50g of solubilizer, 15g of fungicide, 15g of beneficial absorbent, 10g of insect repellent and 5g of preservative.

[0045] The matrix includes at least one of glycerin, water-soluble chitosan, Tween 20, poloxamer, cetyl alcohol, stearyl alcohol, insect wax and hydrogenated vegetable oil.

[0046] The phages include the following raw material components: 30 g of Staphylococcus aureus phages and 30 g of Escherichia coli phages.

[0047] The disinfectant includes the following raw material components: 5g of alkaline phosphatase, 5g of motherwort, 3g of astragalus polysaccharide and 2g of epimedium.

[0048] The beneficial absorbent comprises the following raw material components: 5g of calcium hydrogen phosphate, 5g of glutamic acid, 3g of methionine agent and 2g of vitamin C.

[0049] The insect repellant includes at least o...

Embodiment 2

[0057] A bacteriophage vaginal suppository for livestock, which is made of the following raw materials:

[0058] 225g of matrix, 90g of bacteriophage, 75g of cosolvent, 22.5g of fungicide, 22.5g of beneficial absorbent, 15g of insect repellant and 7.5g of preservative.

[0059] The matrix includes at least one of glycerin, water-soluble chitosan, Tween 20, poloxamer, cetyl alcohol, stearyl alcohol, insect wax and hydrogenated vegetable oil.

[0060] The phages include the following raw material components: 45g of Staphylococcus aureus phages and 45g of Escherichia coli phages.

[0061] The disinfectant includes the following raw material components: 7.5g of alkaline phosphatase, 7.5g of motherwort, 4.5g of astragalus polysaccharide and 3g of epimedium.

[0062] The beneficial absorbent includes the following raw material components: 7.5g of calcium hydrogen phosphate, 7.5g of glutamic acid, 4.5g of methionine agent and 3g of vitamin C.

[0063] The insect repellant includes ...

Embodiment 3

[0071] A bacteriophage vaginal suppository for livestock, which is made of the following raw materials:

[0072] 300g of substrate, 120g of bacteriophage, 100g of cosolvent, 30g of fungicide, 30g of beneficial absorbent, 20g of insect repellant and 10g of preservative.

[0073] The matrix includes at least one of glycerin, water-soluble chitosan, Tween 20, poloxamer, cetyl alcohol, stearyl alcohol, insect wax and hydrogenated vegetable oil.

[0074] The phages include the following raw material components: 60 g of Staphylococcus aureus phages and 60 g of Escherichia coli phages.

[0075] The fungicide includes the following raw material components: 10g of alkaline phosphatase, 10g of motherwort, 6g of astragalus polysaccharide and 4g of epimedium.

[0076] The beneficial absorbent comprises the following raw material components: 10 g of calcium hydrogen phosphate, 10 g of glutamic acid, 6 g of methionine agent and 4 g of vitamin C.

[0077] The insect repellant includes at l...

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Abstract

The invention discloses a bacteriophage vaginal suppository for livestock and a preparation method of the bacteriophage vaginal suppository. The bacteriophage vaginal suppository comprises the following raw material components: 150-300 parts of a matrix, 60-120 parts of bacteriophage, 50-100 parts of a cosolvent, 15-30 parts of a poisoning agent, 15-30 parts of a beneficial absorption agent, 10-20 parts of an insect repellant and 5-10 parts of a preservative. The bacteriophage vaginal suppository has the beneficial effects that the bacteriophage vaginal suppository for the livestock can effectively inhibit germs in vagina of the livestock, and does not generate drug resistance; through the design of the poison killing agent, endotoxin in the vagina can be removed, the body temperature of livestock is prevented from rising, vaccine failure is further avoided, and economic losses are reduced.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations for animal health, in particular to a bacteriophage vaginal suppository for livestock and a preparation method thereof. Background technique [0002] Vaginitis in domestic animals is a common and multiple reproductive organ disease in production. The main causes of its occurrence are postpartum vaginal injury, artificial insemination, lax disinfection, vaginal injury of sows during natural mating, and infection by pathogenic microorganisms through various channels. And cause vaginitis, need to use vaginal suppository to treat. [0003] The field of existing livestock vaginal suppositories, such as Chinese Patent No. CN102512358A, discloses a rifaximin vaginal suppository for livestock and a preparation method thereof, which includes a solid dispersion of rifaximin, a matrix, a surfactant, a synergist, an antiseptic agent, etc., so as to ensure the uniform dispersion of the mai...

Claims

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Application Information

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IPC IPC(8): A61K38/46A61K35/76A61K36/232A61K36/268A61K36/296A61K36/344A61K36/533A61K36/54A61K36/714A61K36/718A61K36/736A61K36/756A61K36/758A61K36/9068A61K9/02A61K47/10A61K47/36A61K47/44A61P15/02A61P31/04A61K31/198A61K31/375A61K31/715A61K33/42
CPCA61K35/76A61K36/533A61K31/715A61K36/296A61K33/42A61K31/198A61K31/375A61K36/736A61K36/758A61K36/54A61K36/344A61K36/268A61K36/9068A61K36/718A61K36/232A61K36/714A61K36/756A61K38/465C12Y301/03001A61K9/02A61K9/0034A61K47/10A61K47/44A61K47/36A61P15/02A61P31/04A61K2300/00
Inventor 丛郁徐旭凌何四龙乔欢肖逍许文建丁良樊小九徐天舜许小康李涛华雨田
Owner PHAGELUX (NANJING) BIO-TECH CO LTD
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