Acidified amoxicillin soluble powder as well as preparation method and application thereof

Abstract

The invention discloses acidified amoxicillin soluble powder which comprises the following components in percentage by weight: 12-36% of amoxicillin, 25-30% of anhydrous citric acid, 5-10% of anhydrous sodium sulfate and the balance of anhydrous magnesium sulfate, and a method comprises the steps of crushing, sieving, mixing and the like. The amoxicillin soluble powder is scientific and reasonable in formula and simple in process, different from common amoxicillin soluble powder, the solubility and the dissolution rate of the amoxicillin soluble powder in water are improved, the maximum solubility reaches 7%, and the amoxicillin soluble powder is stable in water for 24 h after being dissolved; the pH value of the solution is less than 4, gastric acid influence is reduced, animal drinking is facilitated, absorption is promoted, and bioavailability is improved; the effects of disinfecting and cleaning the drinking water system can be achieved; organic acid molecules are competitively and preferentially combined with metal ions and alkaline substances, so that the amoxicillin is protected, and the completeness and full play of the drug effect of the amoxicillin are ensured; the traditional Chinese medicine composition has a good effect on infectious diseases caused by escherichia coli, staphylococcus aureus and salmonella which are sensitive to animals.

Description

technical field [0001] The invention relates to the technical field of veterinary drug preparations, in particular to acidified amoxicillin soluble powder, its preparation method and application. Background technique [0002] Amoxicillin is amoxicillin, the chemical molecule has one more hydroxyl group than ampicillin, and its tolerance and antibacterial effect are stronger than ampicillin. It is one of the widely used oral penicillin products at present. It mainly targets the penicillinase of bacteria, and achieves the purpose of antibacterial by destroying the synthesis of bacterial cell walls, and can kill or inhibit bacteria in the breeding period. It is characterized by a broad antibacterial spectrum, and has strong antibacterial and bactericidal effects on most Gram-positive and Gram-negative bacteria; it is stable under acidic conditions, and the gastrointestinal absorption rate of monogastric animals is 74%-92%; The blood concentration is high, and it can be used fo...

AI Technical Summary

Problems solved by technology

Some amoxicillin soluble powders on the market are easy to absorb moisture and change color; the solubility is too low when dissolving in water, resulting in insufficient drug intake, and some may even appear hot, which affects the stability of amoxicillin after dissolving in water. And due to the structural characteristics of amoxicillin itself, it is easy to deteriorate in water, which limits its application in farms

[0004] It is reported that amoxicillin is made into nanoscale, microcapsules, etc., which greatly delays the efficacy of amoxicillin, but its preparation process is complicated and the production cost is high

[0005] Authorized patent CN104840426B (CN201510298759.7) uses organic acid, stabilizer, co-solvent, carrier, etc. to combine the invention, but its component selection and proportion make the product moisture too high, which does not comply with the Veterinary Pharmacopoeia of the People's Republic of China 》2020 Edition Requirements for Amoxicillin Soluble Powder

[0006] The disclosed invention CN102727491A (CN201210218160.4) uses the combination of anhydrous citric acid and amoxicillin, and carries out ultrafine pulverization. Although the amoxicillin is placed in an acidic environment, the particle size is reduced, and the solubility is increased, the anhydrous citri

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