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Preparation method and application of carbon quantum dot nano assembly

A nano-assembly, carbon quantum dot technology, applied in the field of biomedical materials, can solve problems such as poor sensitivity and accuracy, and unsatisfactory imaging effects, and achieve good ultra-low cost, long in vivo circulation time, and stable structure.

Pending Publication Date: 2022-05-24
NINGBO FIRST HOSPITAL +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the imaging effect of gadolinium-based contrast agents currently used is not very satisfactory. For example, the relaxation rate of gadopentetate meglumine (Gd-DTPA) is generally around 4, and the sensitivity and accuracy are poor.

Method used

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  • Preparation method and application of carbon quantum dot nano assembly
  • Preparation method and application of carbon quantum dot nano assembly
  • Preparation method and application of carbon quantum dot nano assembly

Examples

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Embodiment 1

[0036] A preparation method of a carbon quantum dot nano-assembly that can be used for magnetic resonance imaging, specifically comprising the following steps:

[0037] 1) Weigh 2.15g shellac acid A and dissolve it in 20mL N,N-dimethylformamide to form 0.2mol / L shellac acid A solution;

[0038] 2) The shellac acid A solution obtained in the above step 1) is transferred to a stainless steel hydrothermal synthesis kettle containing a polytetrafluoroethylene lining, put into a muffle furnace, and heats up at a rate of 5°C / min under an air atmosphere To 180 ℃, react for 8 hours, after the reaction, take out the carbonized solution in the hydrothermal synthesis kettle, and pass it through silica gel column chromatography, using ethyl acetate as the eluent, and silica gel column chromatography separation and purification technology to remove excess impurities; Remove the liquid, disperse the obtained powder in 20 mL of ultrapure water, and after standing, use an aqueous microporous ...

Embodiment 2

[0046] The preparation method of the carbon quantum dot nano-assembly that can be used for magnetic resonance imaging in this embodiment specifically includes the following steps:

[0047] 1) Weigh 6.45g of shellac acid A and dissolve it in 40mL of N,N-dimethylformamide to form 0.3mol / L shellac acid A solution;

[0048] 2) The shellac acid A solution obtained in the above step 1) is transferred to a stainless steel hydrothermal synthesis kettle containing a polytetrafluoroethylene lining, put into a muffle furnace, and heated at a rate of 8°C / min under air atmosphere To 200 ℃, react for 6 hours, after the reaction, take out the carbonized solution in the hydrothermal synthesis kettle, and pass it through silica gel column chromatography, using petroleum ether as the eluent, to remove excess impurities by silica gel column chromatography separation and purification technology; then remove the elution The obtained powder was dispersed in 40 mL of ultrapure water. After standing,...

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Abstract

The invention belongs to the technical field of biomedical materials, and relates to a preparation method of a carbon quantum dot nano assembly, which comprises the following steps: 1) adding shellac acid A into an organic solvent until the shellac acid A is dissolved; 2) performing solvothermal reaction on the solution in the step 1) in an air atmosphere, after the reaction, performing silica gel column chromatography separation and purification to remove redundant impurities, then removing the solvent, dispersing the obtained powder in water, standing, performing suction filtration, pouring out supernate, filling the supernate into a dialysis bag, dialyzing in water, and then freeze-drying to obtain the carbon quantum dots; and (3) dispersing the carbon quantum dots obtained in the step (2) into an iron-containing inorganic salt aqueous solution, carrying out ultrasonic reaction for 10-60 minutes, standing, filling into a dialysis bag, dialyzing in water, and freeze-drying to obtain the carbon quantum dot nano assembly. The obtained carbon quantum dot nano assembly can be used as a contrast agent for nuclear resonance imaging.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to a preparation method and application of a carbon quantum dot nanometer assembly. Background technique [0002] Cancer is a kind of disease that seriously endangers human life, health and quality of life. With the continuous advancement of medical technology, the diagnosis and treatment of cancer has moved from empirical medicine and evidence-based medicine to the era of precision medicine. Because precision diagnosis and treatment integrates the functions of diagnosis and treatment, it has obvious advantages over a single diagnosis or treatment method. At present, the imaging-mediated therapy system has become the development trend of modern medical imaging technology. Among them, magnetic resonance imaging (MRI) technology is one of the commonly used technologies for early diagnosis of cancer. Compared with other imaging techniques, MRI has the advantages of high t...

Claims

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Application Information

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IPC IPC(8): C09K11/65A61K49/00B82Y20/00B82Y30/00
CPCC09K11/65A61K49/0067B82Y20/00B82Y30/00
Inventor 高翔董晨吴爱国马雪华
Owner NINGBO FIRST HOSPITAL
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