Application of serum myristic acid as asthma diagnosis marker

A myristic acid and serum technology, which is applied in the fields of instruments, measuring devices, scientific instruments, etc., can solve the problems of inability to diagnose asthma conveniently and accurately, and the sensitivity and specificity of asthma diagnostic markers are not high, and achieve good application prospects, high Effects of sensitivity and specificity

Pending Publication Date: 2022-05-27
ZHONGSHAN HOSPITAL FUDAN UNIV
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Problems solved by technology

[0004] The technical problem to be solved by the present invention is: the markers in the prior art cannot diagnose asthma conveniently and accurately, that is, the existing asthma diagnostic markers have problems such as low sensitivity and specificity

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  • Application of serum myristic acid as asthma diagnosis marker
  • Application of serum myristic acid as asthma diagnosis marker
  • Application of serum myristic acid as asthma diagnosis marker

Examples

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Embodiment

[0022] This example provides the use of serum myristic acid as a diagnostic marker for asthma:

[0023] The collected sera of asthma patients and healthy subjects (experimental group) were analyzed by Q Exactive Orbitrap LC-MS for non-targeted metabolomics, and 12 asthma-related serum core metabolites such as myristic acid were found. The serum myristic acid in asthma patients (17629808.23±20999189.42) was significantly higher than that in healthy people (6940110.31±7041734.38), and the difference was statistically significant (Pfigure 1 shown, and serum myristic acid has a high sensitivity (82.35%) and specificity (77.78%) for diagnosing asthma, the AUC of the ROC curve is 0.801, the results are as follows figure 2 shown. In order to further evaluate the value of serum myristic acid in the diagnosis of asthma, another group of asthmatic patients and healthy subjects were included as the validation group, and targeted metabolomics UHPLC-MRM-MS / MS method was used to detect the...

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Abstract

The invention discloses application of serum myristic acid as an asthma diagnosis marker. According to the present invention, the non-target metabonomics of the serum of the experimental group is analyzed through the Q Exactive Orbitrap LC-MS, such that 12 asthma-related serum core metabolites such as myristic acid are found; wherein the serum myristic acid of an asthma patient is obviously higher than that of a healthy person, the difference has statistical significance, the serum myristic acid has relatively high sensitivity to asthma diagnosis, and the result is verified through a verification group. The serum myristic acid provided by the invention has relatively high sensitivity and specificity as an asthma diagnosis marker, and is simpler and more convenient, so that the serum myristic acid has a good application prospect in diagnosis of asthma.

Description

technical field [0001] The invention relates to the use of serum myristic acid as an asthma diagnostic marker, and belongs to the technical field of detection reagents. Background technique [0002] Bronchial asthma, referred to as asthma, is a chronic respiratory disease characterized by airway inflammation and airway hyperresponsiveness. Asthma is one of the most common chronic diseases in the world. The global prevalence of asthma is about 1% to 18% in different countries, and about 4.2% in China. The total number of asthma patients in the world has exceeded 300 million, which is a serious threat to human health. The diagnosis of asthma in the Global Initiative for Asthma (GINA) in 2021 is still based on clinical manifestations and auxiliary test results such as lung function. There is currently no gold standard for the diagnosis of asthma, and there is no single test method to diagnose ( or exclude) asthma. Therefore, the discovery of a new biomarker with high specific...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/72
CPCG01N30/02G01N30/72
Inventor 陈智鸿朱涛马圆金美玲徐侃闵智慧毛若琳陈梦捷崔博高磊
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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