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Function prediction and screening method of glioblastoma lncRNA coding micropeptide

A glioblastoma and screening method technology, applied in the field of function prediction and screening of glioblastoma lncRNA-encoded micropeptides, can solve the problems of unclear molecular mechanism and frequent tumor recurrence

Inactive Publication Date: 2022-05-27
THE FIRST AFFILIATED HOSPITAL OF WANNAN MEDICAL COLLEGE YIJISHAN HOSPITAL OF WANNAN MEDICAL COLLEGE
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Problems solved by technology

Multidrug resistance, especially to temozolomide, leading to frequent tumor recurrence is a challenge in the treatment of glioblastoma, and the underlying molecular mechanisms are unclear

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  • Function prediction and screening method of glioblastoma lncRNA coding micropeptide
  • Function prediction and screening method of glioblastoma lncRNA coding micropeptide

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Embodiment

[0037] Example: A method for predicting and screening functions of glioblastoma lncRNA-encoded micropeptides, comprising the following steps:

[0038] S1. Screening of glucose transporter gene sets:

[0039] S11. Screen human SWEETs in combination with MSigDB and WikiGene databases;

[0040] S12. Search the pubmed database to collect research data on SWEETs in tumors and gliomas;

[0041] S13. Use the STRING online platform to construct a PPI network for SWEETs, and perform functional enrichment analysis combined with KEGG, Reactomepathway and GO annotations to obtain protein interaction information.

[0042] Significant differential expression and survival analysis of S2, glucose transporter gene set in pan-cancer:

[0043] S21. Download the expression and clinical data of TCGA pan-cancer (https: / / portal.gdc.cancer.gov), and the expression profile data of normal tissues in GEO database (GSE51024) and GTEx database, and extract each tumor and normal tissue respectively data...

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Abstract

The invention discloses a function prediction and screening method of glioblastoma lncRNA coding micropeptides. The method comprises the following steps: screening a glucose transporter gene set; carrying out significant differential expression and survival analysis on the glucose transporter gene set in the pan cancer; verifying the SLC2A10 in the glioblastoma, and predicting ceRNA (Ribonucleic Acid); the method comprises the following steps: carrying out LINC02381 coding to predict the micro-peptide, positioning the predicted micro-peptide into a human chromosome, carrying out identification and function enrichment analysis on the predicted micro-peptide, and reserving the micro-peptide which has the same chromosome as the LINC02381 and is predicted to have potential functions. The invention provides a function prediction and screening method of glioblastoma lncRNA (long non-coding RNA) coded micropeptide, and provides a basis for researching the effect of the lncRNA coded micropeptide in glioblastoma in prognosis or diagnosis.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a method for predicting and screening functions of a glioblastoma lncRNA-encoded micropeptide. Background technique [0002] Oncology research is increasingly becoming a serious public health problem worldwide. In 2020, the ICGC / TCGA pan-cancer analysis of whole genomes (PCAWG) project conducted the most comprehensive tumor genome analysis of 2658 tumor genomes included in 38 tumor types, aiming to compare and analyze different tumor genomes. Similarities and differences between genomic and cellular changes found in tumor types. Glioma is the most common and most aggressive primary intracranial tumor in the central nervous system. Induced by factors, mainly manifested as increased intracranial pressure, neurocognitive dysfunction and epileptic seizures, resulting in damage to the central nervous system, endangering the patient's life. Glioblastoma (GBM) is a gr...

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Application Information

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IPC IPC(8): G16B15/30G16B25/10
CPCG16B15/30G16B25/10
Inventor 蒋澜吕坤童九翠王祖贞钟民杨建课邓汉诺罗天乐冯翔杜金锐汪乐瑶
Owner THE FIRST AFFILIATED HOSPITAL OF WANNAN MEDICAL COLLEGE YIJISHAN HOSPITAL OF WANNAN MEDICAL COLLEGE
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