Noninvasive subcutaneous tissue fluid extraction-detection device and extraction-detection method

A detection device, subcutaneous tissue technology, applied in blood characterization devices, diagnostic recording/measurement, medical science, etc., can solve problems such as skin irritation and damage, susceptibility to infection, blood collection pain, etc., to reduce skin irritation and damage, and low prices. , the use of a wide range of effects

Active Publication Date: 2022-05-31
UNIVERSITY OF CHINESE ACADEMY OF SCIENCES +1
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Problems solved by technology

[0007] The purpose of the present invention is to provide a non-invasive subcutaneous tissue fluid extraction-detection device and extraction-detection method in order to overcome the defects of skin irritation and damage, blood collection pain, and susceptibility to existing tissue fluid detection technology. The electrodes of the extraction-detection device The system can prov...

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  • Noninvasive subcutaneous tissue fluid extraction-detection device and extraction-detection method
  • Noninvasive subcutaneous tissue fluid extraction-detection device and extraction-detection method
  • Noninvasive subcutaneous tissue fluid extraction-detection device and extraction-detection method

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Embodiment 1

[0101] A non-invasive subcutaneous tissue fluid extraction - detection device, such as Figure 1Shown, comprising an adhesionable substrate 103, a first electrode assembly, a second electrode assembly, a current source (not shown in the figure) and an electrochemical detection and analysis apparatus (not shown in the figure), the second electrode assembly comprises a "turn" shaped extraction electrode positive electrode 102, extraction electrode positive wire 101, the first electrode assembly comprises a sequentially disposed fiber paper, carbon electrode layer, potassium ferrocyanide layer, glucose oxidase layer, gel layer of paper-based flexible bioelectrode, gel layer close to the skin 200. The carbon electrode layer is comb-shaped and interdigitated, such as Figure 8 as shown. The comb-shaped fork finger type carbon electrode layer is conducive to homogenization of the extracted electric field. The electrode of the present embodiment adopts a fiber paper as the substrate, a hig...

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Abstract

The invention belongs to the technical field of medical diagnostic instruments, and particularly relates to a noninvasive subcutaneous tissue fluid extraction-detection device and method, the extraction-detection device comprises an adhesive substrate, a first electrode assembly and a second electrode assembly, the first electrode assembly comprises an extraction/detection electrode layer, and the extraction/detection electrode layer comprises double electrodes; the second electrode assembly comprises an extraction electrode positive electrode which is used for being matched with one electrode in the double electrodes so as to percutaneously extract subcutaneous tissue fluid through a reverse iontophoresis technology; the extraction electrode positive electrode coats the extraction/detection electrode layer, and the extraction electrode positive electrode extends along the coated edge of the extraction/detection electrode layer. The extraction-detection device provided by the invention can provide an electrode system with a more uniform electric field, can extract a detected amount of tissue fluid sample under a working current as low as 0.1 mA, and reduces discomfort such as skin irritation and injury; the electrode is compact in structure and high in measurement accuracy.

Description

Technical field [0001] The present invention belongs to the field of medical diagnostic instrument technology, specifically relates to a non-invasive subcutaneous tissue fluid extraction - detection device and extraction - detection method. Background [0002] Today, invasive detectors are still widely used for the extraction and detection of tissue fluids, but because of the trauma and pain, patients still try to avoid such invasive tests as much as possible. Therefore, minimally invasive and non-invasive testers become the hope of patients. [0003] Non-invasive tissue fluid extraction - detection, as the name suggests, refers to the extraction and detection of subcutaneous tissue fluid without causing damage to human skin tissue. There are many existing methods for the detection of non-invasive microstructure fluids, which can be roughly divided into two categories: optical method and electrochemical method. Among them, optical methods mainly include near-infrared spectroscopy...

Claims

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Application Information

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IPC IPC(8): A61B5/1477A61B5/145
CPCA61B5/14514A61B5/1477
Inventor 刘仁材陈靖容周玉龙
Owner UNIVERSITY OF CHINESE ACADEMY OF SCIENCES
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