Application of miR-30a-5p as vascular injury repair molecular target

A technology of 1. mir-30a-5p, mir-30a-5pmimics, applied in the application field of miR-30a-5p as a molecular target for vascular damage repair, can solve the problem of limited angiogenesis speed, and achieve the effect of improving vitality

Inactive Publication Date: 2022-06-07
NANTONG UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The purpose of the present invention is to solve the technical problem of limited regeneration speed after blood vessel damage in the prior art

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  • Application of miR-30a-5p as vascular injury repair molecular target
  • Application of miR-30a-5p as vascular injury repair molecular target
  • Application of miR-30a-5p as vascular injury repair molecular target

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Embodiment Construction

[0038] In order to make the objectives, technical solutions and advantages of the present invention clearer, the present invention will be further described in detail below with reference to specific embodiments.

[0039] Many specific details are set forth in the following description to facilitate a full understanding of the present invention, however, the present invention may also be implemented in other ways than those described herein, and therefore, the present invention is not limited to the specific embodiments of the following disclosure. limit.

[0040] MicroRNAs (miRNAs) are endogenous, non-coding, small RNAs of approximately 20-24 nucleotides in length, which inhibit target gene translation or directly degrade target genes by binding to the untranslated region at the 3' end of the target gene. miRNAs can regulate the proliferation, migration and angiogenesis of various cells including vascular endothelial cells and vascular smooth muscle cells, and affect the repa...

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Abstract

The invention provides an application of miR-30a-5p as a vascular injury repair molecular target, and relates to the technical field of biological pharmacy, the miR-30a-5p and mimics of the miR-30a-5p are used as molecular intervention targets, the miR-30a-5p is over-expressed, and the activity, migration and tube forming ability of HUVECs are improved. According to the invention, the HUVECs are cultured in vitro, miR-30a-5p mimic is transfected, and the activity, migration and tube forming capability of the HUVECs can be obviously improved. The miR-30a-5p provided by the invention can participate in vascular injury repair by regulating the activity, migration and tube formation of vascular endothelial cells, is beneficial to better understanding the important effect of miRNA in the vascular injury repair process, and provides a new target spot for treatment after vascular injury.

Description

technical field [0001] The invention relates to the technical field of biopharmaceuticals, in particular to the application of miR-30a-5p as a molecular target for vascular damage repair. Background technique [0002] Vascular injury is often accompanied by various tissue and organ injuries, which brings a great burden to clinical treatment and injury recovery. Although blood vessels can regenerate spontaneously after injury, due to the limited regeneration speed, insufficient blood supply limits the diffusion of oxygen in the damaged tissue, resulting in delayed recovery of damaged tissue and even secondary damage. The relationship between them has received increasing attention in recent years. Fully exploring the cellular and molecular mechanisms of vascular injury regeneration will help promote vascular injury repair and provide a theoretical basis for clinical treatment. SUMMARY OF THE INVENTION [0003] The purpose of the present invention is to solve the technical ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883A61K31/7088A61P25/02A61P9/14C12N5/10C12N15/87
CPCC12Q1/6883A61K31/7088A61P25/02A61P9/14C12N5/069C12N15/87C12Q2600/158C12Q2600/178C12Q2600/136C12N2510/00
Inventor 周松林丁斐杜明智张琦从猛贺倩茹
Owner NANTONG UNIVERSITY
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