Traditional Chinese medicine composition for treating diabetic peripheral neuropathy as well as preparation method and application of traditional Chinese medicine composition

A technology for peripheral neuropathy and composition, applied in the directions of drug combination, nervous system diseases, pharmaceutical formulations, etc., can solve the problems that the treatment method is difficult to achieve the therapeutic effect, lack of specificity, etc., achieves the treatment of diabetic peripheral neuropathy, reduces fasting The effect of blood sugar and grip strength

Pending Publication Date: 2022-07-05
XIYUAN HOSPITAL OF CHINA ACAD OF CHINESE MEDICAL SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, many drugs only temporarily relieve DPN pain and do not target the underlying mechanism causing DPN pain
Moreover, the curre

Method used

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  • Traditional Chinese medicine composition for treating diabetic peripheral neuropathy as well as preparation method and application of traditional Chinese medicine composition
  • Traditional Chinese medicine composition for treating diabetic peripheral neuropathy as well as preparation method and application of traditional Chinese medicine composition
  • Traditional Chinese medicine composition for treating diabetic peripheral neuropathy as well as preparation method and application of traditional Chinese medicine composition

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Effect test

Example Embodiment

[0046] Example

[0047] Each raw material is weighed according to the prescription ratio in the following table 1 to prepare the traditional Chinese medicine composition of the present invention.

[0048] Table 1

[0049]

[0050] The traditional Chinese medicine compositions in each embodiment of the present invention are prepared according to the following methods, including the following steps:

[0051] (1) take by weighing safflower, astragalus, salvia miltiorrhiza, licorice, dried tangerine peel, soil soft-shelled turtle according to the prescription ratio, place in a round-bottomed flask, add 10 times the amount of distilled water, heat under reflux for 1.5 hours, filter while hot, and the filter residue is re-extracted for 1.5 hours, The two filtrates were combined, concentrated under reduced pressure on a rotary evaporator to obtain a concentrated solution, volatilized in a water bath, concentrated into an extract, dried in a vacuum drying oven, and ground into fine...

Example Embodiment

[0063] Example 1 Take 5.73g of the drug powder obtained in step (1), add distilled water to dissolve to 15ml;

Example Embodiment

[0064] Example 2 Take 6.58g of the drug powder obtained in step (1), add distilled water to dissolve to 15ml;

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Abstract

The invention provides a traditional Chinese medicine composition for treating diabetic peripheral neuropathy. The traditional Chinese medicine composition is prepared from safflower carthamus, astragalus membranaceus, salvia miltiorrhiza, myrrh, liquorice, pericarpium citri reticulatae and ground beeltle. The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps of: (1) weighing the safflower, the astragalus membranaceus, the salvia miltiorrhiza, the liquorice, the pericarpium citri reticulatae and the ground beeltle according to the prescription proportion, and performing water extraction and alcohol precipitation to obtain mixture powder of the safflower, the astragalus membranaceus, the salvia miltiorrhiza, the liquorice, the pericarpium citri reticulatae and the ground beeltle; (2) extracting volatile oil of myrrh, and mixing the volatile oil with beta-cyclodextrin to obtain inclusion compound powder of the volatile oil of myrrh; and (3) the powder obtained in the step (1) and the powder obtained in the step (2) do not need to be mixed, and the powder is weighed according to the prescription proportion during administration. The invention also provides application of the traditional Chinese medicine composition in preparation of medicines or medicaments for treating diabetic peripheral neuropathy. Pharmacological tests prove that the traditional Chinese medicine composition has a good treatment effect on diabetic peripheral neuropathy.

Description

technical field [0001] The invention relates to the field of medicinal chemistry, in particular to a traditional Chinese medicine composition for treating diabetic peripheral neuropathy, a preparation method and application thereof. Background technique [0002] Diabetic peripheral neuropathy (DPN) is a chronic complication of diabetes that occurs in up to half of people with diabetes and damages the peripheral and autonomic nervous systems. The pathogenesis of diabetic peripheral neuropathy mainly involves increased poly ADP-ribose polymerase (ADRP) activity, accumulation of advanced glycation end products (AGEs), activation of the diacylglycerol-PKC pathway, oxidative stress, mitochondrial dysfunction, neuroinflammation and Neuronal apoptosis, etc. The clinical symptoms of patients are usually symmetrical numbness of the extremities, low-grade fever, hypoalgesia and needle-like pain, which seriously affect the quality of life of the patients. [0003] The treatment of di...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61K47/69A61P3/10A61P25/02A61K35/64
CPCA61K36/286A61K36/481A61K36/537A61K36/328A61K36/484A61K36/752A61K35/64A61K47/6951A61P3/10A61P25/02A61K2236/331A61K2236/55A61K2236/51A61K2300/00Y02A50/30
Inventor 任钧国杜阳张伏芝雷蕾周雪忠刘建勋孟硕于清源李磊
Owner XIYUAN HOSPITAL OF CHINA ACAD OF CHINESE MEDICAL SCI
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