Polyether-ether-ketone biological composite powder as well as preparation method and application thereof

A technology of polyether ether ketone and composite powder, which is applied in the direction of processing and manufacturing, prosthesis, coating, etc., can solve the problems of matrix material degradation, surface thermal properties and laser absorption properties, etc., to promote crystallization, improve mechanical properties, The effect of enhancing the binding force

Active Publication Date: 2022-07-08
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, it also solves the problem that the matrix material is degraded due to the change of surface thermal properties and laser absorption properties of polyetheretherketone composite materials during the forming process.

Method used

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  • Polyether-ether-ketone biological composite powder as well as preparation method and application thereof
  • Polyether-ether-ketone biological composite powder as well as preparation method and application thereof
  • Polyether-ether-ketone biological composite powder as well as preparation method and application thereof

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preparation example Construction

[0036] see figure 1 , the present invention provides a preparation method of polyether ether ketone biological composite powder, the preparation method uses polyether ether ketone powder as a matrix, and uses Ca(NO 3 ) 2 ·4H 2 0 and Na 3 PO 4 As a precursor, a specific salt is used as the element source of the desired element, and a hydrothermal co-deposition reaction is used to co-deposit a nano-hydroxyapatite coating containing specific elements on the surface of the polyether ether ketone powder. The specific steps are as follows:

[0037] (1) Screening medical grade polyetheretherketone powder with a particle size of 10-100 μm, and performing surface modification on it by oxygen plasma method to introduce polar groups.

[0038] Among them, the oxygen plasma treatment was performed on the polyetheretherketone powder to introduce polar groups, and then the bonding force between the co-deposited layer and the polyetheretherketone matrix was greatly improved by increasing ...

Embodiment 1

[0061] (1) Powder plasma treatment: screen 400g of medical grade polyetheretherketone powder with a particle size of 10-100μm, put the polyetheretherketone powder into a low-temperature plasma treatment instrument, adjust the instrument parameters to 50W, and the vacuum degree to 25Pa , the oxygen flow is 50mL / min, and the plasma treatment is 10min.

[0062] (2) Co-deposition treatment: choose Ca(NO 3 ) 2 ·4H 2 0 solution as Ca source, Na 3 PO 4 As P source, Sr(NO 3 ) 2 As the required Sr source, Mg(NO 3 ) 2 As the required Mg source, add 9 mol Ca(NO) to 1 L of deionized water 3 ) 2 ·4H 2 0.6molNa 3 PO 4 , 0.5mol Sr(NO 3 ) 2 , 0.5mol Mg(NO 3 ) 2, after stirring evenly, add a pH adjuster to make the pH value reach 8 to obtain a co-deposition reaction solution, add the co-deposition reaction solution to a 2L reaction kettle, and then add plasma-treated polyether ether ketone powder. The co-deposition reaction was carried out under the conditions that the tempera...

Embodiment 2

[0065] (1) Powder plasma treatment: screen 200g of medical grade polyetheretherketone powder with a particle size of 10-100μm, put the polyetheretherketone powder into a low-temperature plasma treatment instrument, adjust the instrument parameters to 100W, and the vacuum degree to 25Pa , the oxygen flow is 20mL / min, and the plasma treatment is 20min.

[0066] (2) Co-deposition treatment: choose Ca(NO 3 ) 2 ·4H 2 0 solution as Ca source, Na 3 PO 4 As P source, AgNO 3 As the required Ag source, AuNO 3 As the required Au source, add 4 mol Ca(NO) to 500 ml of deionized water 3 ) 2 ·4H 2 0,3mol Na 3 PO 4 , 1mol AgNO 3 , 1mol AuNO 3 , after stirring evenly, a pH adjuster was added to make the pH value reach 8.5 to obtain a co-deposition reaction solution. The co-deposition reaction solution was put into a reaction kettle with a volume of 1 L, and then the plasma-treated polyetheretherketone powder was added. The co-deposition reaction was carried out under the conditio...

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Abstract

The invention belongs to the related technical field of biological composite materials, and discloses polyether-ether-ketone biological composite powder as well as a preparation method and application thereof, and the preparation method comprises the following steps: (1) carrying out surface modification on polyether-ether-ketone powder by adopting oxygen plasma; (2) Ca (NO3) 2.4 H2O serving as a Ca source, Na3PO4 serving as a P source, X (NO3) y serving as a required functional element source and a pH regulator are added into deionized water to obtain a co-deposition reactant, then the polyether-ether-ketone powder is added into the co-deposition reactant for a co-deposition reaction, and then polyether-ether-ketone biological composite powder is obtained; and X comprises any one or more of an antibacterial element, an element with immune regulation and anti-cancer functions, an element with photo-thermal anti-cancer properties and an element with vascularization promotion properties. The polyetheretherketone biological composite powder obtained by the invention can simultaneously have the characteristics of osteogenesis, antibiosis, immunoregulation, cancer resistance and the like.

Description

technical field [0001] The invention belongs to the technical field of biological composite materials, and more particularly, relates to a polyether ether ketone biological composite powder and a preparation method and application thereof. Background technique [0002] Polyetheretherketone is a semi-crystalline polymer, which not only has excellent biocompatibility, chemical stability, wear resistance and elastic modulus matching human cortical bone, but also has no artifacts in CT or MRI images , does not affect postoperative imaging analysis, so it has a wide range of clinical applications. On the other hand, due to the need for personalized and complex porous lattice implants in orthopaedic clinics, 3D printing technology has become an effective way to prepare PEEK bone implants. Laser selective sintering is a mainstream 3D printing technology. It is based on the idea of ​​discrete stacking and forming. According to the interface information of each layer of the CAD mode...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/32A61L27/50A61L27/54A61L27/30B29C64/153B33Y10/00B33Y70/00B33Y80/00
CPCA61L27/18A61L27/32A61L27/50A61L27/54A61L27/306B29C64/153B33Y10/00B33Y70/00B33Y80/00A61L2430/02A61L2400/12A61L2300/104A61L2300/102A61L2300/404A61L2300/426A61L2300/416A61L2300/606C08L61/16Y02P10/25
Inventor 闫春泽王浩则袁熙陈鹏苏瑾伍宏志张贞杨操史玉升
Owner HUAZHONG UNIV OF SCI & TECH
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