A kind of bioactive bone composite material and its preparation method and application

A technology of composite materials and modified materials, which is applied in the field of composite materials for bone and its preparation, can solve the problems of immune rejection, mismatch of mechanical properties, low bioactivity of osteoconduction and osteoinduction, etc., and achieve the promotion of bone formation and effective bone Effect of defect repair, high compressive strength and compressive modulus

Active Publication Date: 2022-03-08
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, traditional artificial bone materials also have disadvantages such as low osteoconductive and osteoinductive bioactivity, mismatched mechanical properties, and immune rejection.

Method used

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  • A kind of bioactive bone composite material and its preparation method and application
  • A kind of bioactive bone composite material and its preparation method and application
  • A kind of bioactive bone composite material and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Example 1 Porous scaffolds were prepared using low-temperature deposition rapid prototyping 3D printing technology.

[0073]Using the established and optimized computer model of the structure and composition, the controllable preparation is carried out through the control of the manufacturing process parameters of the low-temperature deposition rapid prototyping 3D printing technology, so as to meet the special needs of various osteogenic material structures.

[0074] Forming raw material preparation: Dissolve the biodegradable polymer PLGA in the organic solvent 1,4-dioxane, stir to make it fully dissolved, and then pour the mixed solution into a low-temperature rapid deposition system for 3D printing to prepare magnesium silicide composite porous stand.

[0075] Molding and preparation of porous scaffolds: According to the selected ingredients, the preparation raw materials are mixed and placed in the material tank of the low-temperature deposition rapid prototyping s...

Embodiment 2

[0077] Example 2: PLGA / χMS magnesium silicide composite porous scaffold: the mass fraction of magnesium silicide is 10%.

[0078] The composite porous scaffold was prepared by the same preparation method as in Example 1. The difference from the preparation method in Example 1 is that in the preparation process of the molding raw materials, after dissolving the biodegradable polymer PLGA in the organic solvent 1,4-dioxane and stirring to fully dissolve it, magnesium silicide is added The particles are evenly dispersed in it, and then the mixed solution is poured into a low-temperature rapid deposition system for 3D printing to prepare a composite porous scaffold of magnesium silicide. The added amount of magnesium silicide particles is 10% of the mass of the composite porous support.

Embodiment 3

[0079] Example 3: PLGA / χMS magnesium silicide composite porous scaffold: the mass fraction of magnesium silicide is 20%.

[0080] The composite porous scaffold was prepared by the same preparation method as in Example 1. The difference from the preparation method in Example 1 is that in the preparation process of the molding raw materials, after dissolving the biodegradable polymer PLGA in the organic solvent 1,4-dioxane and stirring to fully dissolve it, magnesium silicide is added The particles are evenly dispersed in it, and then the mixed solution is poured into a low-temperature rapid deposition system for 3D printing to prepare a composite porous scaffold of magnesium silicide. The added amount of magnesium silicide particles is 20% of the mass of the composite porous support.

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Abstract

The invention relates to a composite material for bioactive bone and its preparation method and application. Specifically disclosed is a composite material for bone, characterized in that the composite material for bone includes a substrate of a biodegradable polymer, and the substrate also contains magnesium silicide; the biodegradable polymer is selected from Degradation occurs to produce small molecular organic acids. The invention discovers for the first time the special effect of magnesium silicide acting on the bone injury site. The invention uses the biodegradable polymer substrate to degrade under the physiological environment to generate small molecular organic acids, which makes the environment around the bracket slightly acidic, thus triggering the growth of magnesium silicide. Degradation, to achieve the controllable release of long-term magnesium ions and silicon ions along with the degradation process of the stent, and play a role in promoting bone activity; at the same time, it can regulate the formation of hypoxic microenvironment at the implantation site and promote angiogenesis. The magnesium silicide-containing composite material for bone of the present invention exhibits biological activities of promoting osteogenesis and angiogenesis, and can realize effective bone defect repair.

Description

technical field [0001] The invention belongs to the field of biomaterials, and in particular relates to a composite material for bone with osteogenesis and angiogenesis activity, a preparation method and application thereof. Background technique [0002] Bone defect is the destruction of the structural integrity of bone tissue, the loss of part of the bone mass, and the formation of large gaps between bone tissues. Various traumas, diseases (such as osteoporosis, bone tumors, osteonecrosis, etc.) or operations are common factors causing bone defects. Due to the existence of bone defects, bone nonunion, delayed union or even nonunion, and local dysfunction are often caused. The repair and functional reconstruction of large bone defects that cannot heal on their own have always been a major challenge in orthopedic clinics. If they cannot be effectively repaired, the rate of disability and deformity will be very high, which will seriously affect the postoperative quality of li...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/46A61L27/44A61L27/58
CPCA61L27/46A61L27/446A61L27/58A61L2430/02A61L2300/102A61L2300/604
Inventor 张卫赖毓霄龙晶聂杨逸秦岭
Owner SHENZHEN INST OF ADVANCED TECH
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