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Construction method of low-grade glioma pyroptosis related lncRNA prognosis model

A technology of glioma cells and construction method, which can be applied in the field of construction of lncRNA prognostic model related to pyroptosis of low-grade glioma cells, which can solve the problems of unclear prognosis evaluation of lncRNA and low-grade glioma patients.

Pending Publication Date: 2022-07-08
郑州源创基因科技有限公司 +1
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Problems solved by technology

Previous studies have reported that gasdermin-related proteins play an important role in tumor-induced pyroptosis and tumor immunity, but the current study found that in glioma, non-coding RNA-hsa_circ_0001836 was proved to be down-regulated to induce NLRP1 up-regulation to promote glioma cells pyroptosis occurs
In addition, the relationship between pyroptosis-related lncRNA and the prognosis of patients with low-grade glioma is still unclear

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  • Construction method of low-grade glioma pyroptosis related lncRNA prognosis model
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  • Construction method of low-grade glioma pyroptosis related lncRNA prognosis model

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[0021] In order to make the objectives, technical solutions and advantages of the embodiments of the present invention clearer, the following will be combined with the appendixes of the embodiments of the present invention. Figure 1-5 , to clearly and completely describe the technical solutions of the embodiments of the present invention. Obviously, the described embodiments are some, but not all, embodiments of the present invention. Based on the described embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art fall within the protection scope of the present invention.

[0022] A method for constructing a low-grade glioma cell pyroptosis-related lncRNA prognosis model, comprising the following steps: Step 1: data source and processing, and screen out the survival information of low-grade glioma patients and lncRNAs strongly related to cell pyroptosis ; Implemented in the following way: download the RNA sequencing data and c...

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Abstract

The invention provides a construction method of a low-grade glioma pyroptosis related lncRNA prognosis model, and belongs to the technical field of medicines.The construction method comprises the steps that low-grade glioma patient transcriptome sequencing and clinical data related data are collected from a TCGA database, lncRNA is screened through a Pearson correlation algorithm, and the low-grade glioma pyroptosis related lncRNA prognosis model is obtained; the pyroptosis related lncRNA is explored through a single-multi-factor cox regression method, a model is constructed, immune related analysis is carried out on the model by adopting GSEA, immune infiltration and ssGSEA, and an important reference basis is provided for treatment and prognosis of clinical low-grade glioma patients.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a method for constructing a low-grade glioma cell pyroptosis-related lncRNA prognosis model. Background technique [0002] Gliomas are the most common intracranial malignancies and are traditionally divided into low-grade gliomas and high-grade gliomas. Low-grade gliomas refer to WHO grade 1-2 gliomas. With the development of molecular detection and sequencing technologies, the distinction between low-grade gliomas and high-grade gliomas has shifted from histology to molecular markers. With reference to molecular status such as IDH and 1p / 19q, the misdiagnosis probability of glioma based on traditional histology is about 6% to 35%. In 2016, WHO carried out a molecular classification of gliomas, pointing out that molecular features have an important impact on the diagnosis and prognosis of gliomas. Therefore, accurate diagnosis and molecular targeted therapy are of great signif...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H50/30G16B20/00G06F17/18
CPCG16H50/30G06F17/18G16B20/00
Inventor 徐茜赵辉高萧芳孙宪凯姚伦广
Owner 郑州源创基因科技有限公司
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