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Application of peripheral blood neutrophil as severe asthma diagnostic marker

A technology for neutrophils and severe asthma, applied in the field of biomedical testing, can solve problems such as inconvenient and accurate diagnosis of severe asthma

Pending Publication Date: 2022-07-15
ZHONGSHAN HOSPITAL FUDAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The present invention aims to provide peripheral blood neutrophils as a diagnostic marker for severe asthma, so as to solve the technical problem that the markers in the prior art cannot diagnose severe asthma conveniently and accurately

Method used

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  • Application of peripheral blood neutrophil as severe asthma diagnostic marker
  • Application of peripheral blood neutrophil as severe asthma diagnostic marker
  • Application of peripheral blood neutrophil as severe asthma diagnostic marker

Examples

Experimental program
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Effect test

Embodiment

[0024] This example provides the use of peripheral blood neutrophils as diagnostic markers for severe asthma:

[0025] First, a group of severe and non-severe asthma patients were recruited, peripheral blood and induced sputum were collected from the patients, and the number and proportion of peripheral blood neutrophils and the proportion of induced sputum neutrophils were detected. The comparison between the two groups showed that the absolute value of blood neutrophils in patients with severe asthma (5.24±1.87 109 / L vs. 3.64±1.25 109 / L, Pfigure 1 shown. Linear regression was performed on the proportion of neutrophils in the peripheral blood and induced sputum of asthma patients, and the results showed that the two were positively correlated (β=1.171, P=0.006), as shown in figure 2 shown. When judging whether peripheral blood neutrophils can be used as the diagnostic standard for severe asthma, a diagnostic test method is used, and the "guideline standard" is defined as th...

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Abstract

The invention discloses application of peripheral blood neutrophil as a severe asthma diagnosis marker. The invention provides application of peripheral blood neutrophil as a marker in preparation of a product for diagnosing severe asthma. According to the present invention, the determination index of severe asthma is obtained by detecting the absolute value and / or the ratio of the peripheral blood neutrophil through the blood routine test of the asthma patient, such that the determination index of severe asthma is determined as follows: the absolute value gt of the peripheral blood neutrophil; 4.55 * 10 < 9 > / L (the sensitivity is 83.3%, and the specificity is 64.0%) or the percentage gt of the neutrophils in the peripheral blood; when the sensitivity is 54.8% and the specificity is 88.0%, the severe asthma is judged, and the AUC of the ROC curve is 0.777 and 0.762 respectively. Results of the invention show that compared with sputum induction, the peripheral blood neutrophil which is more rapid and convenient to detect has a good application prospect in the diagnosis of severe asthma.

Description

technical field [0001] The invention relates to the use of peripheral blood neutrophils as diagnostic markers for severe asthma, and belongs to the technical field of biomedical detection. Background technique [0002] As a common clinical disease, the global prevalence of asthma has been increasing in recent years. Most asthma patients can be controlled or better improved by standard drug treatment, but 5% to 10% of severe patients are still difficult to control. [0003] The diagnosis of severe asthma is carried out according to the expert consensus of GINA and the asthma group of the Respiratory Branch of the Chinese Medical Association. Generally, the disease control can only be achieved by the application of grade 4 or 5 anti-asthma treatment or the disease is difficult to control once the treatment grade is lowered. Therefore, the judgment of severe asthma is generally delayed, and a period of follow-up observation of specific patients is required to accurately diagnos...

Claims

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Application Information

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IPC IPC(8): G01N33/96G01N33/50G01N33/569
CPCG01N33/96G01N33/5091G01N33/56966G01N2333/435G01N2800/60G01N2800/12
Inventor 陈智鸿毛若琳朱蕾闵智慧崔博朱振华
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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