Callicarpa bodinieri compound preparation and preparation method and application thereof

A technology of compound preparations and purple beads, which is applied in the direction of medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of application of veterinary drug preparations in anti-inflammatory and hemostatic compound prescriptions, and achieve Improve the effect of antibacterial, anti-inflammatory and hemostatic cooling, the extraction method is safe and effective, and the effect of prolonging the residence time

Pending Publication Date: 2022-07-26
广东梅州职业技术学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] It is worth noting that so far, in the prevention and control of bacterial diseases in livestock and poult

Method used

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  • Callicarpa bodinieri compound preparation and preparation method and application thereof

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preparation example Construction

[0038] The preparation steps of the reference solution include: accurately weighing appropriate amounts of luteolin reference substance, verbascoside reference substance, and rehmanlin reference substance, and adding 70% methanol to prepare a mixed reference substance containing 20 μg luteolin and 40 μg verbascoside per 1 mL. solution, that is.

[0039] The preparation steps of the test solution include: taking about 1 g of this product, accurately weighing it, placing it in a conical flask with a stopper, adding 50 mL of 70% methanol precisely, weighing it, and ultrasonically treating it (power 500W, frequency 40KHz) for 40 minutes, Allow to cool, weigh again, use 70% methanol to make up the lost weight, shake well, filter, and take the filtrate.

[0040] The active ingredient determination method is to precisely draw 10 μL of the reference solution and the test solution, respectively, and inject them into a liquid chromatograph for determination.

[0041] This product is ca...

Embodiment 1

[0044] The invention provides a Zizhu compound preparation. Calculated according to the total weight percentage of the compound preparation, Nude violacea: Echinacea = 2:1, and glycerol monostearate is added in an amount of 60 wt%.

[0045] Operation steps: (1) Cut the medicinal materials of Echinacea and Echinacea into about 5cm pieces, add 14 times of water, decocted for 3 times, decocted for 1 hour each time, combined the decoction, centrifuged at 2000rpm for 10 minutes, at 85 ℃ and concentrated under reduced pressure to a relative density of 1.3 to obtain a thick paste state of the medicinal material extract, and the contents of luteolin and verbascoside were determined (the contents were 0.075wt% and 0.934wt% respectively), and it was used for later use.

[0046] (2) Weigh the weight of the thick paste (medicinal material extract) in step (1), take 60% glycerol monostearate by weight, stir and dissolve at 80 ° C, add the thick paste obtained in step 1, stir well, press 10...

Embodiment 2

[0048] The invention provides a compound preparation of Chinese veterinary medicine Zizhu. According to the total weight percentage of the compound preparation, Muzizhu: Diul=3:1, and stearic acid is added in an amount of 60wt%.

[0049] Operation steps: (1) Cut Muzizhu and Diyu medicinal materials into about 5cm pieces, add 24 times of water, decocted for 2 times, decocted for 1 hour each time, combined the decoction, centrifuged at 2000rpm for 10 minutes, at 80 ℃ concentrated under reduced pressure to a relative density of 1.3 to obtain a thick paste state of the medicinal material extract, and the contents of luteolin and verbascoside were determined (the contents were 0.065wt% and 0.873wt% respectively), and it was used for later use.

[0050] (2) Weigh the weight of the thick paste (medicinal material extract) in step (1), take 60% stearic acid by weight, stir and dissolve at 80 ° C, add the thick paste obtained in step 1, stir well, and add by weight percentage 10wt% cyc...

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Abstract

The invention provides a callicarpa bodinieri compound preparation as well as a preparation method and application thereof, and the callicarpa bodinieri compound preparation comprises a first medicinal material and a second medicinal material which account for 40-90wt% of the total weight of the callicarpa bodinieri compound preparation, a carrier accounting for 10 to 60 wt%; wherein the first medicinal material is a verbenaceae callicarpa plant medicinal material; the weight ratio of the first medicinal material to the second medicinal material is 1: 1-3: 1. Therefore, the compound preparation with a sustained and controlled release function is formed by the extract containing the verbenaceae callicarpa plant component and the high-molecular compound (carrier) through a certain process, so that the aim of preventing and treating bacterial diseases by utilizing the plant extract is fulfilled.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese veterinary medicines, in particular to a compound preparation of traditional Chinese veterinary medicines prepared from violacea plant and a preparation method and application thereof. Background technique [0002] In the prevention and control of bacterial diseases in livestock, poultry and aquatic products, the application of traditional Chinese veterinary drugs has broad prospects. According to research, there are about 190 species of Verbena plants, mainly distributed in tropical and subtropical regions of Asia and Oceania. my country There are about 46 species, mainly distributed in the south of the Yangtze River, of which about 30 species can be used for medicinal purposes, stems and leaves or the whole plant are used as medicine, the nature is flat, the taste is bitter, it belongs to the liver, spleen and lung meridians, and has the functions of promoting blood circulation, hemost...

Claims

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Application Information

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IPC IPC(8): A61K36/85A61K36/898A61K36/889A61K36/88A61K36/896A61K47/14A61K47/12A61K47/32A61K47/10A61K47/40A61K47/36A61K47/38A61K47/18A61K9/16A61P31/04A61K35/36
CPCA61K36/85A61K36/739A61K36/47A61K36/28A61K36/898A61K36/73A61K36/889A61K36/88A61K35/36A61K36/14A61K36/185A61K36/489A61K36/74A61K36/896A61K36/804A61K47/14A61K47/12A61K47/32A61K47/10A61K47/40A61K47/36A61K47/38A61K47/18A61K9/1617A61P31/04A61K2236/331A61K2236/39A61K2300/00
Inventor 李美娣赵仁发吉艺宽邹导夫蔡孟楷贾聪俊徐炜琳李少方梁权明张梦玲
Owner 广东梅州职业技术学院
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