Skeleton-type callicarpa bodinieri sustained-release granule

A slow-release granule and skeleton-type technology, applied in the field of slow-release preparations, can solve problems such as degradation and inability to release, and achieve the effects of easy storage, improved efficiency, and simple preparation method.

Pending Publication Date: 2022-08-05
广东梅州职业技术学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the above, the present invention provides a skeleton-type purple bead sustained-release granule and its preparation method and application. Through a certain process, the purple bead extract and polymer compound are made into a skeleton mosaic state to form a sustained-release granule. And the active ingredients are released during the gradual erosion of the skeleton, which solves the technical problem that the active ingredients of plant extracts are degraded in gastric acid or cannot be released in the intestinal tract, so as to achieve the purpose of using plant extracts to prevent and treat bacterial diseases

Method used

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  • Skeleton-type callicarpa bodinieri sustained-release granule
  • Skeleton-type callicarpa bodinieri sustained-release granule
  • Skeleton-type callicarpa bodinieri sustained-release granule

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preparation example Construction

[0029] The steps of the preparation method of skeleton type Zizhu sustained-release granules of the present invention include:

[0030] The preparation step S1 of the Zizhu extract: cut the plant into pieces of about 5 cm, add 8 to 24 times of deionized water, decocted for 2 consecutive times, decocted for 1 hour each time, combined the decoction, and centrifuged at 2000rpm For 10 min, the supernatant was taken and concentrated under reduced pressure at 85°C to a relative density of 1.3 to obtain the purple pearl extract;

[0031] Preparation step S2 of skeleton type Zizhu sustained-release granules: stirring and dissolving the carrier at 40-80° C., adding the Zizhu extract obtained in step S2, fully stirring, spraying and granulating, after cooling, passing through a 40-mesh sieve, namely The skeleton type Zizhu sustained-release granules were obtained.

[0032] In the production method embodiment of the present invention, the purple bead extract is at least one plant select...

Embodiment 1

[0044] The skeleton type Zizhu sustained-release granules provided in Example 1, calculated according to the total weight percentage of the granules, are the extracts of Nasturtium vulgaris, accounting for 10 wt%; polyethylene glycol 12000, accounting for 90 wt%.

[0045] Steps:

[0046] (1) Cut the medicinal material of Nasturtium vulgaris into about 5cm pieces, add 12 times of water, decocted for 2 times, decocted for 1 hour each time, combined the decoction, centrifuged at 2000rpm for 10min, and concentrated under reduced pressure at 85°C to a relatively low pressure. The density was 1.3, and the extract of Nasturtium chinensis was obtained, which was identified by thin layer chromatography and assayed for the content of luteolin and verbascoside, and was used for later use. Among them, this product is calculated as dry product, containing luteolin (C 21 H 20 O 11 ) 0.085%; containing Verbasin (C 29 H 36 O 15 ) shall not be less than 1.27%)

[0047] (2) Dissolve poly...

Embodiment 2

[0049] The skeleton type Zizhu sustained-release granules provided in Example 2 are calculated according to the total weight percentage of the granules, and the loquat leaf Zizhu extract accounts for 20wt%; stearic acid accounts for 80wt%.

[0050] Steps:

[0051] (1) Cut the loquat leaf Zizhu medicinal material into about 5cm pieces, add 20 times of water, decocted for 2 times, decocted for 1 hour each time, combined the decoction, centrifuged at 2000rpm for 10min, and concentrated under reduced pressure at 85°C to a relative density of 1.3 , obtain the loquat leaf Zizhu extract extract, carry out thin-layer chromatography identification and luteolin glycyrrhiza and verbascoside content determination, standby. Among them, this product is calculated as dry product, containing luteolin (C 21 H 20 O 11 ) 0.083%; containing Verbasin (C 29 H 36 O 15 ) shall not be less than 1.14%

[0052] (2) Dissolve stearic acid by stirring at 40°C, add the extract of loquat leaf purple p...

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Abstract

The invention provides a skeleton-type callicarpa bodinieri sustained-release particle and a preparation method and application thereof, and the skeleton-type callicarpa bodinieri sustained-release particle comprises the following components in percentage by weight: 5-40wt% of a callicarpa bodinieri extract and 60-95wt% of a carrier. According to the invention, the callicarpa bodinieri extract and the skeleton type particle carrier are combined into a skeleton embedded state to form the sustained-release particles, and the effective components are released in the process of gradual corrosion of the skeleton, so that the technical problem that the effective components of the plant extract are degraded in gastric acid or cannot be released in intestinal tracts is solved; the purpose of preventing and treating bacterial diseases by using the plant extract is achieved.

Description

technical field [0001] The invention relates to the technical field of sustained and controlled release preparations, in particular to skeleton-type sustained-release granules and a preparation method and application thereof. Background technique [0002] There are about 190 species of Verbena, mainly distributed in tropical and subtropical regions of Asia and Oceania. There are about 46 species in my country, mainly distributed in the south of the Yangtze River, of which about 30 species can be used medicinally. The strain is used as medicine, with flat nature, bitter taste, and belongs to the liver, spleen and lung meridians, and has the functions of promoting blood circulation, stopping bleeding, removing heat and detoxifying. Mainly used to treat hematemesis, hemoptysis, blood in the stool, metrorrhagia, traumatic bleeding, carbuncle swollen poison, throat paralysis, rheumatoid arthritis, irregular menstruation, burns, etc. A variety of plants of the genus Viola has a lo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/85A61K9/16A61K47/10A61K47/36A61K47/32A61K47/12A61K47/14A61K47/18A61K47/38A23K10/30A23K40/10A61P31/04A61P29/00
CPCA61K36/85A61K9/1641A61K9/1652A61K9/1617A61K9/1635A61P31/04A61P29/00A23K10/30A23K40/10Y02A40/70
Inventor 李美娣赵仁发吉艺宽曾富兰邹导夫
Owner 广东梅州职业技术学院
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