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Application of olfactory mucosa mesenchymal stem cells in preparation of medicines for treating epilepsy diseases

A technology of mesenchymal stem cells and mucous membranes, applied in the field of antiepileptic drugs, can solve problems such as drug refractory, achieve the effects of reducing demyelination and neuron loss, increasing expression, and improving cognitive function

Pending Publication Date: 2022-07-29
卢明
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  • Claims
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AI Technical Summary

Problems solved by technology

60% to 70% of epilepsy patients can be controlled by antiseizure medications (ASMs), but about 30% to 40% are drug refractory, that is, the seizures cannot be controlled after rational use of two ASMs. refractory epilepsy

Method used

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  • Application of olfactory mucosa mesenchymal stem cells in preparation of medicines for treating epilepsy diseases
  • Application of olfactory mucosa mesenchymal stem cells in preparation of medicines for treating epilepsy diseases
  • Application of olfactory mucosa mesenchymal stem cells in preparation of medicines for treating epilepsy diseases

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Embodiment 1

[0030] 1. Acquisition, culture and identification of human olfactory mucosal mesenchymal stem cells (refer to patent CN201711318656.8):

[0031] Human-derived olfactory mucosa mesenchymal stem cells were obtained from healthy subjects, and the operation was performed after signing the voluntary consent form and the approval of the ethics committee. Before the operation, clean the nose hair and add chloramphenicol drops, four times a day, two drops each time for three consecutive days. Before obtaining the nasal mucosa, intranasal infiltration anesthesia was performed, and 2 to 3 tissue pieces with a diameter of about 0.5 cm were taken from the medial root of the middle turbinate. After the nasal mucosa tissue block was taken out, it was immediately stored in low-temperature PBS; then, the high-glucose DMEM / F12 medium containing penicillin 200U / ml and streptomycin 200U / ml was rinsed 3 times to remove blood stains, and then transferred to containing 10% fetal bovine serum ( Compl...

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Abstract

The invention relates to application of olfactory mucosa mesenchymal stem cells in preparation of drugs for treating epilepsy diseases, and belongs to the technical field of anti-epileptic drugs. The invention provides application of olfactory mucosa mesenchymal stem cells in preparation of a medicine for treating epilepsy diseases. The olfactory mucosa mesenchymal stem cells can relieve symptoms and times of epileptic seizure, realize treatment of epilepsy and relieve inflammatory immune response, so that the brain tissue microenvironment is improved, repair of damaged neurons is promoted, and encephalatrophy caused by intractable epilepsy is finally reversed.

Description

technical field [0001] The invention relates to the technical field of antiepileptic drugs, in particular to the application of olfactory mucosal mesenchymal stem cells in the preparation of drugs for treating epilepsy diseases. Background technique [0002] Epilepsy is a chronic neurological disease in which abnormal discharge of neurons leads to transient disturbance of brain function. 60% to 70% of epilepsy patients can be controlled by antiseizure medications (Antiseizure medications, ASMs), but about 30% to 40% are drug refractory, that is, the seizures cannot be controlled after rational use of two ASMs. for refractory epilepsy. Recurrent epileptic seizures have varying degrees of impact on patients' cognition and behavior, brain function development in children, and the quality of life of patients and their families. Therefore, it is of great clinical significance to seek treatment methods for epilepsy, especially intractable epilepsy. SUMMARY OF THE INVENTION ...

Claims

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Application Information

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IPC IPC(8): A61K35/28A61P25/08A61P25/00A61P37/02A61P29/00
CPCA61K35/28A61P25/08A61P25/00A61P37/02A61P29/00
Inventor 卢明谢辉黄雁刘征兆
Owner 卢明
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