Preparation method of qi depression and blood heat stasis syndrome model

A technology of blood heat and blood stasis syndrome, which is applied in the field of preparation of qi stagnation, blood heat and blood stasis syndrome model, and has achieved good application prospects

Pending Publication Date: 2022-08-05
陆华 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, in the process of TCM treatment, there is often a mixture of multiple syndromes. How to prepare a multi-syndrome model is a di

Method used

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  • Preparation method of qi depression and blood heat stasis syndrome model
  • Preparation method of qi depression and blood heat stasis syndrome model
  • Preparation method of qi depression and blood heat stasis syndrome model

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1. Construction of the syndrome model of qi stagnation and blood heat with stasis

[0045] 1. Experimental materials

[0046] 1.1 Experimental animals

[0047] Mature female SD rats, SPF grade, weight 280-320g, 12 weeks old, provided by Chengdu Dashuo Technology Co., Ltd., animal license number: SCXK (Chuan) 2020-066, animal feed was ordinary solid feed (Chengdu Dashuo) Technology Co., Ltd.).

[0048] 1.2 Experimental drugs

[0049] Levothyroxine sodium tablets (Uthyroxine), produced by Merck Serono, specification: 50μg*100 tablets / box, product batch number: 600Q98, 600M0T.

[0050] 2. Experimental method

[0051] 1.1 Drug preparation

[0052] Preparation of levothyroxine sodium tablet suspension: The dosage of levothyroxine sodium tablet for modeling was determined to be 1 mg / kg. 200 levothyroxine sodium tablets with a specification of 50 μg / tablet were made into powder (the active ingredient levothyroxine was 10 mg in total), and the volume was adjusted ...

Embodiment 2

[0134] Example 2. Screening of drugs for preventing and / or treating the syndrome of qi stagnation and blood heat with stasis by using the model of the present invention

[0135] (1) according to the preparation method of embodiment 1, establish a syndrome model of qi stagnation and blood heat with stasis;

[0136] (2) Administering the candidate drug to a model of syndrome of qi stagnation and blood heat with stasis;

[0137] (3) To observe the influence of candidate drugs on various indicators, and to evaluate potential drugs for the prevention and / or treatment of qi stagnation and blood heat with stasis syndrome.

Embodiment 3

[0138] Example 3. Screening of drugs for preventing and / or treating thyrotoxicosis using the thyrotoxicosis model of the present invention

[0139] (1) establish a thyrotoxicosis model according to the preparation method of Example 1;

[0140] (2) administering the candidate drug to a thyrotoxicosis model;

[0141] (3) To observe the influence of candidate drugs on various indicators, and to evaluate potential drugs for preventing and / or treating thyrotoxicosis.

[0142] To sum up, the present invention uses levothyroxine sodium to induce and construct a thyrotoxicosis model. The animal model has a syndrome of liver stagnation and blood heat with stasis, which can be used as a compound syndrome of qi stagnation and blood heat with stasis. Syndrome model. The invention provides a new syndrome model for traditional Chinese medicine research, provides a new method for traditional Chinese medicine drug screening, and has a good application prospect.

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Abstract

The invention provides a preparation method of a qi depression and blood heat stasis syndrome model, and belongs to the technical field of traditional Chinese medicine syndrome models. The model for the syndrome of qi depression and blood heat with blood stasis is formed by using levothyroxine sodium or pharmaceutically acceptable salt thereof. According to the invention, levothyroxine sodium is utilized to induce and construct a thyroid toxin model, the syndrome type of the animal model is liver depression and blood heat clamping stasis, and the thyroid toxin model can be used as a qi depression and blood heat clamping stasis syndrome model with composite syndrome characteristics. A new syndrome model is provided for traditional Chinese medicine research, a new method is provided for traditional Chinese medicine medication screening, and good application prospects are achieved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine syndrome models, and particularly relates to a preparation method of a syndrome model of qi stagnation and blood heat with stasis. Background technique [0002] Syndrome refers to a certain stage of the disease process, the disease location, etiology, disease nature, disease state and the strength of the body's resistance to disease and other essential and organically related reaction states, manifested as clinically observable symptoms, etc. Among them, Qi stagnation syndrome and blood heat syndrome are the common syndrome types in traditional Chinese medicine. [0003] Qi stagnation syndrome refers to the pathological changes caused by the poor movement of Qi in the body and staying in a certain part. Common clinical symptoms are liver qi stagnation and spleen and stomach qi stagnation. Qi stagnation syndrome is a common syndrome in traditional Chinese medicine. The main s...

Claims

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Application Information

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IPC IPC(8): A01K67/027A61K31/198A61K49/00
CPCA01K67/027A61K31/198A61K49/0008A01K2207/20A01K2227/105A01K2267/035Y02A50/30
Inventor 陆华王通刘芊辰
Owner 陆华
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