Application of tortoise plastron in preparation of medicine for treating brain aging and bone aging

A brain aging and drug technology, applied in drug combination, medical formula, bone disease, etc., can solve problems such as tortoise shell, which has not been seen in single drug, and achieve the effect of improving exploration ability and spatial memory, increasing quantity, and improving bone tissue shape

Pending Publication Date: 2022-08-05
THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Tortoise shell is the plastron and carapace of turtles. There is no report that tortoise shell can improve the bone aging of naturally aging mice (22-month-old mice), and there is no report that a single drug tortoise shell can simultaneously treat the comorbidities of brain aging and bone aging. to report

Method used

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  • Application of tortoise plastron in preparation of medicine for treating brain aging and bone aging
  • Application of tortoise plastron in preparation of medicine for treating brain aging and bone aging
  • Application of tortoise plastron in preparation of medicine for treating brain aging and bone aging

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Embodiment 1

[0026] In this example, natural aging mice were used to conduct experiments to study the therapeutic effect of turtle shell on brain aging combined with bone aging.

[0027] 1. Materials

[0028] 1. Animals: 2-month-old female C57BL / 6 mice (18-22g) were purchased from the Experimental Animal Center of Guangzhou University of Traditional Chinese Medicine (license number: SCXK (Guangdong) 2018-0034) and raised in the First Affiliated of Guangzhou University of Traditional Chinese Medicine The SPF animal room of the hospital (license number: SYXK (Guangdong) 2018-0092) was raised to 22 months to make a natural aging mouse model (weight 27-33g), which is the classic SOP model. The experiment was approved by Guangzhou University of Traditional Chinese Medicine. Approved by the Ethics Committee of the First Affiliated Hospital.

[0029] 2. Medicines, reagents and instruments: turtle shell (The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, batch ...

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Abstract

The invention provides application of tortoise plastron in preparation of drugs for resisting brain aging and bone aging. The tortoise plastron can improve the exploration ability and spatial memory of naturally aged mice, effectively delay the aging of hippocampus, increase the number of hippocampus CA3 region nissl's bodies, and improve the bone microstructure and bone tissue morphology of naturally aged mice. Therefore, the tortoise plastron can be used for treating brain senescence and bone senescence co-related diseases, such as osteoporosis combined with Alzheimer's disease, and the effect of treating brain senescence combined with bone senescence by a single medicine is achieved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to the application of turtle shell in the preparation of a medicine for treating brain aging combined with bone aging. Background technique [0002] Comorbid diseases related to brain aging and bone aging (such as osteoporosis combined with Alzheimer's disease, etc.) have brought a huge burden to patients, families and socioeconomics. At present, there is no drug that can specifically reverse brain aging and bone aging at the same time, so it is urgent to explore the therapeutic drugs for the co-morbidity of brain aging and bone aging. As a high-level regulatory center of the hypothalamus-pituitary-gonad (HPG) axis, the hippocampus plays an important role in bone homeostasis by regulating the release of sex hormones from the HPG axis, which is the physiological basis for the co-morbidity of brain aging and bone aging . [0003] Turtle shell is the p...

Claims

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Application Information

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IPC IPC(8): A61K35/586A61P19/10A61P25/28
CPCA61K35/586A61P19/10A61P25/28Y02A40/81
Inventor 任辉尚奇江晓兵沈耿杨陈桂锋余富勇张鹏陈弘林招文华余翔张志达刘慧雯
Owner THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU UNIV OF CHINESE MEDICINE
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