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Antineoplastic compound Intercedenside C in Sea Cucumber Mensamaria Intercedens

A technology of anti-tumor drugs and compounds, applied in the field of medicine

Inactive Publication Date: 2004-11-17
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The chemical structure and antitumor activity of the contained saponins have not been reported so far

Method used

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  • Antineoplastic compound Intercedenside C in Sea Cucumber Mensamaria Intercedens
  • Antineoplastic compound Intercedenside C in Sea Cucumber Mensamaria Intercedens

Examples

Experimental program
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Embodiment Construction

[0063] Further describe the separation and preparation of Intercedenside C by the following examples

[0064] Choose 1000 grams of Ginseng bicolor grown in the sea area of ​​Fujian, China, soak and extract with 5 times the amount (weight) of 95%, 85%, and 85% ethanol in sequence, and soak for 7 days each time. Combine ethanol extracts, recover ethanol under reduced pressure, and obtain liquid extract. The liquid extract was dissolved in 3 times the amount of water, filtered, and the filtrate was passed through a D101 macroporous resin column, and eluted with water and 50% ethanol in turn. Collect the 50% ethanol eluate, recover the solvent under reduced pressure to dryness, and obtain 4.6 grams of total saponins. The total saponins were subjected to silica gel column chromatography, eluted with a mixed solvent of dichloromethane:methanol:water at a ratio of 7:3:1, and the fractions containing Intercedenside C were collected, followed by C 18 Reversed-phase column chromatogra...

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Abstract

The present invention relates to an antitumor Intercedenside C separated from bicolorous zhuopianshen (a Chinese sea-plant), and its molecular formula is C55H83O27SNa. After modern spectral analysis, specially after comprehensive analysis by using several advanced two-D nuclear magnetic resonancespectroscopy the chemical structure and 3-D configuration of said compound can be defined, and the tests show that said compound possesses obvious effect for inhibiting 10-odd tumor cell strain of IP-9 carcinoma of ovary and A-549 human carcinoma of lung, etc. It can provide pilot compound for developing new antitumor medicine.

Description

technical field [0001] The invention relates to the technical field of medicine, and is a new antitumor compound Intercedenside C isolated from marine animal ginseng. Background technique [0002] Mensamaria intercedens Lampert (Mensamaria intercedens Lampert) is a sea cucumber species that grows in large numbers along the coast of Fujian Province, and belongs to the genus Mensamaria intercedens Lampert. The body shape is small, the body length is less than 10cm, the diameter is less than 3cm, and the body wall is thin. It is rich in protein, vitamin A and vitamin E, and has high nutritional value. It is reported in the literature that this animal is also rich in proteoglycans, polysaccharides and saponins (Wu Pingru et al., Research on the chemical constituents of Ginseng bicolor, China Marine Medicine, 2000, 19(1): 17). The chemical structure and antitumor activity of the contained saponins have not been reported so far. Contents of the invention [0003] The present ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/585A61P35/00C07J71/00
Inventor 易杨华邹峥嵘吴厚铭吴久鸿李玲刘宝姝
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY