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Method for preparing mannitol utilizing dextrose

A technology of glucose and mannitol, which is applied in the field of preparation of hexahydric alcohols, can solve the problems of low total dry matter concentration of the solution, increase the steps of evaporation and concentration, and increase the discharge of three wastes, so as to achieve a stable separation effect and reduce the amount of three wastes Emissions and the effect of reducing energy consumption

Inactive Publication Date: 2005-08-24
谭卫星
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after chromatographic separation, the resulting solution has a lower concentration of total dry matter
As a result, the step of evaporative concentration has to be added in the subsequent process
In this way, not only the process is complicated and the cost is increased; but also in industrial production, when using chromatographic separation technology for separation, it is often necessary to use acid, alkali, calcium chloride and other chemical reagents to transform the resin used, thus increasing the cost of the three wastes. emission, which is not conducive to environmental protection
In addition, during industrialized production, the calcium in the resin is continuously lost as the production progresses. Therefore, the separation effect will fluctuate greatly with the continuous regeneration of the resin, which is not conducive to the control of process conditions in production.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Add 300ml of glucose solution with a concentration of 69% in a 500ml reaction bottle, add ammonium molybdate to the solution by 0.25% of the dry matter weight of glucose, and after it dissolves, adjust the pH value of the solution to 4.0 with 30% hydrochloric acid , heated to 105°C, and kept for 2 hours for epimerization. Sampling was detected by high-performance liquid chromatography (Shimadzu RID-10A), and the mannose component accounted for 30.7%, and the glucose component accounted for 69.3%.

[0024] The resulting solution was added to a 500ml beaker, and the beaker was placed in a TDA-8002 temperature-adjusting water bath, and stirred by a D-7401 stepless speed-regulating electric stirrer at a stirring speed of 8 rpm. When the temperature drops to 43°C, add dry glucose seeds (produced by Shijiazhuang Huaying Glucose Factory) accounting for 2% of the total weight of dry matter in the solution to the solution, and then lower the temperature of the solution to crysta...

Embodiment 2

[0026] According to the method shown in Example 1, 300 ml of glucose solution with a concentration of 71.7% was epitropically formed into a mixed solution of glucose and mannose. Among them, the mannose component accounts for 30.4%, and the glucose component accounts for 69.6%. Gained solution is added in the 500ml beaker, and the beaker is placed in the temperature-regulating water bath, stirs with the electric stirrer of stepless speed regulation, and stirring speed is 2 rpm. After the temperature dropped to 36° C., 4% dry glucose seeds were added to the solution, and the temperature was kept at a constant temperature for 4 hours. Then the temperature of the solution was lowered at a gradient of 0.4°C / h for crystallization. After 48 hours of crystallization, the obtained glucose crystals were vacuum filtered to filter out the crystals. The mannose component in the crystallization mother liquor accounts for 37.6%, and the recovery rate of the total sugar in the mother liquo...

Embodiment 3

[0028] According to the method shown in Example 1, 300 ml of glucose solution with a concentration of 72% was epitropically formed into a mixed solution of glucose and mannose. Among them, the mannose component accounts for 29.3%, and the glucose component accounts for 70.7%. Gained solution is added in the 500ml beaker, and the beaker is placed in the temperature-regulating water bath, is stirred with stepless speed regulation electric stirrer, and stirring speed is 5 rpm. When the temperature dropped to 38° C., 10% wet glucose seed crystals (produced by Shijiazhuang Huaxing Pharmaceutical Chemical Factory) were put into the solution, and the temperature was maintained for 4 hours. Then the temperature of the solution was lowered at a gradient of 0.5°C / h for crystallization. After 42 hours of crystallization, the obtained glucose crystals were vacuum filtered to filter out the crystals. The mannose component in the crystallization mother liquor accounts for 36.2%, and the r...

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PUM

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Abstract

The invention relates to a process for preparing mannitol by using glucose as raw material, which comprises the steps of, converting glucose solution partly into mannose under acidic condition at temperature 60-160 deg. C by using molybdates as catalyst, separation by crystallization, converting part of the residual glucose in the mother liquid after separation by crystallization into fructose through glucose isomerase column, obtaining the miscible liquid of glucose, mannose and fructose, hydrogenation for obtaining the miscible liquid of sorbic alcohol and mannose, wherein the mannitol crystal can be prepared through the crystallization and purification of miscible liquids.

Description

technical field [0001] The invention relates to a method for preparing hexahydric alcohol, in particular to a method for preparing mannitol from glucose. Background technique [0002] In the prior art, mannitol can be produced by hydrogenating mannose or fructose. The process of converting glucose into mannose (using molybdate as a catalyst) was reported in the 1970s (Chem. Zvesti., 26, P183-186 (1972)). US Patent 4173514 discloses a method for preparing mannitol from glucose using molybdate as a catalyst. Its preparation includes the following steps: glucose is catalyzed by molybdate to produce mannose, the remaining glucose is acted on by glucose isomerase to partially produce fructose, and the mixed solution is hydrogenated to obtain a mixed alcohol solution containing mannitol. However, this method prepares mannitol, and its yield is very low, only 40-42%. [0003] Chinese patent ZL97106616.7 discloses a preparation method of D-mannitol: D-glucose is first converted t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C29/14C07C31/26
Inventor 谭卫星苏同芳容文谦
Owner 谭卫星
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