Active component of muskrat fragrant, preparing technique and usage

An active component and a preparation process technology, applied in the field of extracting the active components of muskrat, can solve the problems of easy rancidity, deterioration and loss of activity, difficult to preserve, short fresh-keeping period, etc., and achieve the effects of strong pharmacological action and good medicinal prospect.

Inactive Publication Date: 2006-01-25
吉林康乃尔药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The aroma of the original fragrance secreted by muskrats cannot be directly used as a fragrance. The saturated bonds of macrocyclic ketones, fatty acids and esters must be opened to form unsaturated bonds such as ethylenic or acetylenic bonds, so as to fully show the fragrance of muskrats. As the original face of natural animal spices, incense reflects the spice value of its muskrat incense and the effect of refreshing drugs, and the natural muskrat incense contains a large amount of saturated fatty acids which also affects its efficacy; Short term, long-term storage is prone to rancidity and loss of activity, so in order to improve the efficacy and application of muskrat incense, it is necessary to study the processing technology of natural muskrat incense

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] This example relates to the pharmacological activity experiment of the active components of muskrat incense according to the present invention.

[0061] 1. Safety experiment of muskrat incense active components

[0062] 1. Acute toxicity test in mice

[0063] A, oral administration: get 10 small white mice, female, half and half male, body weight 20 ± 2.0g, make the normal saline solution of 50% muskrat incense and pour in the stomach by 820mg / kg muskrat incense, observe after three days without any only death.

[0064] B, injection administration, get 10 small white mice, female, male half and half, body weight 20 ± 2.0g, with the saline solution of 10% muskrat incense intraperitoneal injection 1000mg / kg administration, calculate by simplified probability unit method, record :

[0065] LD 50 (Ip)=15.14+6.52g / kg LD 50 (iv)=13.14+3.58g / kg

[0066] 2. Allergy test on mice

[0067] Give mice a tail vein injection of muskrat incense 770mg / kg, observe for 72 hours, no...

Embodiment 2

[0129] Muskrats were provided by Zuojia Institute of Special Products, Chinese Academy of Agricultural Sciences. Non-anesthesia method Artificial living body incense method to collect natural muskrat incense, saponify the natural muskrat incense with 70% methanol solution of 1MKOH three times the amount of muskrat incense at 60 ° C, reflux for 5 hours, distill off the methanol solution, and concentrate to the original solution After adding 1 / 3 of the solution, add 4 times of water to dilute, after adding 2M H 2 SO 4 Acidification, the pH value is controlled at 2, and the amount of ether added is 15 times that of the solution, and the extraction speed is 50 rpm. The extraction liquid is combined, and the ether is recovered by evaporation with a 35°C rotary evaporator. Anhydrous sodium sulfate is dried to obtain total fatty acid, and its amount is 60% of natural muskrat fragrance amount;

[0130] Then at 20°C, the resulting total fatty acids were esterified with diazomethane-b...

Embodiment 3

[0133] Muskrats were provided by Zuojia Institute of Special Products, Chinese Academy of Agricultural Sciences. Non-anesthesia method artificial living body incense method to collect natural muskrat incense, extract with ethanol-ether (1:2) of 5 times the amount of muskrat incense, evaporate and drive off the solvent, and use 2 times of 1.5M NaOH 80 The % ethanol solution was refluxed, refluxed for 8 hours, the ethanol solution was evaporated, concentrated to 1 / 2 of the original solution, diluted with 2 times of water, acidified by adding 1M HCL, the pH value was controlled at 3, and the solution was added with 10 times the amount of the solution Acetone, extract 8 times, the extraction speed is 30 rpm, combine the extracts, use a 35 ℃ rotary evaporator to evaporate and recover the acetone, and dry it with anhydrous sodium sulfate 5 times the amount of the solution to obtain total fatty acids, the amount of which is natural muskrat incense 80% of the volume;

[0134] Then, u...

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Abstract

An active component of muskrat's musk contains C1-C28 fatty acid and other esters, large-ring ketone, and steroid. Its preparing process includes saponifying natural muskrat's musk in alkaline alcohol solution, acidifying by stone acid, extracting by ether, methylesterifying reaction, and oxidizing degradation reaction. Its advantages are high stability and high output rate. Said active component can replace musk.

Description

technical field [0001] The invention relates to an active component of muskrat incense, a preparation process and application thereof, more precisely, the active component of muskrat incense is extracted from muskrat sachet secretions. Background technique [0002] At home and abroad, musk is regarded as a precious natural fragrance, and it is used as a high-grade fragrance fixative to slowly disperse the fragrance. At the same time, musk is also a famous and precious traditional Chinese medicine, which has the functions of "opening all orifices, opening meridians", promoting blood circulation, dispelling stagnation, and relieving pain. Diseases such as ulcers. Musk prescriptions play an extremely important role in medicine. Many famous Chinese patent medicines in my country, such as Xiaoerhuichun Pills, Liushen Pills, Pien Tze Huang, Hongling San, Musk Bezoar Prescription, Musk Realgar Pills, Borneol Garcinia Prescription, etc., all have musk compatibility. Medicinal musk...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/56A61P7/02A61P9/10A61P29/00A61P43/00
Inventor 宋治国
Owner 吉林康乃尔药业有限公司
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