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Process method for preparing sodium chloride injection of ginkgo leaf extract

A technology of sodium chloride injection and extract, which is applied in the direction of medical raw materials derived from Ginkgo biloba, medical preparations containing active ingredients, drug delivery, etc., which can solve unreasonable process routes, low total amount of active ingredients, and industrialization. Conditions are not met and other problems, to achieve the effect of meeting clinical needs, low production cost, high extraction rate

Inactive Publication Date: 2006-10-25
AOLING BODA MEDICINE SCI & TECH DEV BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main problems in the existing technology: the total amount of active ingredients extracted is not high, the process route is not reasonable enough, or the industrialization conditions are not available, etc.

Method used

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Examples

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Effect test

preparation example Construction

[0020] The preparation of the ginkgo leaf extract of the present invention uses the ginkgo leaves as raw materials. Ginkgo biloba leaves are picked in autumn when they are still green, removed from impurities, and dried in the sun. The selected ginkgo leaves contain more than 0.85% of total flavonol glycosides and more than 0.25% of total terpene lactones.

[0021] The preparation method is as follows:

[0022] 1. Extraction: crush the dried ginkgo leaves to 10-20 mesh, extract several times with 65-85% ethanol, combine the extracts, filter, recover ethanol, and concentrate to a thick paste.

[0023] The influence of ginkgo leaf fineness on the extraction effect is that too fine crushing will not only increase impurities, but also affect the proposal of total flavonol glycosides and total terpene lactones. It is more suitable to use 10-20 mesh broken leaves for extraction. The particle size range of ginkgo leaves determined by the present invention is It is 10-20 mesh.

[0...

Embodiment 1

[0058] Embodiment 1: the preparation of Ginkgo biloba extract

[0059] Crush 1000g of dried ginkgo leaves to below 10-20 mesh, extract three times with 75% ethanol, add alcohol 12 times for the first time, soak for 1.0 hour, reflux extraction for 1.0 hour, add 8 and 6 times the amount for the second and third times respectively , were refluxed and extracted for 0.5 hours, the extracts were combined, filtered, ethanol was recovered under reduced pressure, concentrated to a thick paste, 500m120% ethanol was added, stirred evenly, refluxed and extracted for 0.5 hours, filtered, the precipitation was treated once again in the same way, and the filtrates were combined. Stir and add 60ml of 1% chitosan solution to flocculate, let stand, centrifuge, recover ethanol from the supernatant until it has no alcohol smell, add water to an appropriate amount, inject the sample (2ml / g) into the treated polyamide column, wash with 10% ethanol Elute, collect and elute to a set amount, then elut...

Embodiment 2

[0060] Embodiment 2: Preparation of ginkgo biloba extract sodium chloride injection

[0061] Raw material weight ratio: Ginkgo biloba extract 20g, absolute ethanol 240g (300ml), sodium chloride 900g, water for injection added to 100,000g (100,000ml).

[0062] The preparation method is as follows:

[0063] (1) Take by weighing 20g of Ginkgo biloba extract, add dehydrated alcohol 300ml to dissolve;

[0064] (2) Dilute with 10000ml of water for injection, add 900g of sodium chloride, dissolve, and adjust the pH value of the solution to 4.9 with NaOH solution.

[0065] (3) Add activated carbon (0.2% g / v) to filter and remove impurities, add water for injection to 100,000ml, stir well, measure the pH value and the content of total flavonoids and total terpene lactones, filter, and pour under local 100-level conditions Pack into 100ml / bottle, press the cap, and sterilize at 100°C for 30 minutes.

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Abstract

The invention relates to a preparation method of ginkgo leaf extract sodium chloride injection, which belongs to the technical field of traditional Chinese medicine preparation. The total content of total flavones and total terpene lactones in the ginkgo leaf extract reaches more than 80%, wherein the total flavonoids reach more than 70%, the flavonol glycosides reach more than 40%, and the total terpene lactones content reaches more than 10%. The preparation method of the ginkgo leaf extract sodium chloride injection of the present invention comprises the steps of liquid preparation, filtration, potting, sterilization and the like. The extraction process route of the ginkgo leaf extract of the invention is reasonable, and the processes of extraction, impurity removal, purification, extraction, column separation and refining meet the requirements of large-scale production and meet industrial conditions. The ginkgo leaf extract sodium chloride injection of the invention provides a new dosage form of the ginkgo leaf extract for clinical use, does not produce allergic reactions and hemolysis, and has no irritation to blood vessels through intravenous injection. It can be used directly during use, is more convenient than small needles or freeze-dried products, and has wide application in the field of cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The invention relates to a preparation method of ginkgo biloba extract sodium chloride injection, in particular to a raw material drug and preparation for treating cardiovascular and cerebrovascular diseases, peripheral blood vessels and other blood circulation disorders, and belongs to the technical field of traditional Chinese medicine preparation. Background technique [0002] Blood circulation disorders such as cardiovascular and cerebrovascular diseases and peripheral blood vessels are one of the most common clinical diseases and a major class of diseases that affect people's health and longevity. The role of Ginkgo biloba extract and its preparations in cardiovascular and cerebrovascular diseases and peripheral vascular diseases has attracted more and more attention from all over the world. Ginkgo biloba L. is an ancient relic plant, also known as ginkgo tree. Ginkgo biloba is a rare tree species in my country and a precious medicinal plant reso...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K36/16A61K9/08A61P9/00
Inventor 庄洪波
Owner AOLING BODA MEDICINE SCI & TECH DEV BEIJING
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