Process method for preparing sodium chloride injection of ginkgo leaf extract
A technology of sodium chloride injection and extract, which is applied in the direction of medical raw materials derived from Ginkgo biloba, medical preparations containing active ingredients, drug delivery, etc., which can solve unreasonable process routes, low total amount of active ingredients, and industrialization. Conditions are not met and other problems, to achieve the effect of meeting clinical needs, low production cost, high extraction rate
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[0020] The preparation of the ginkgo leaf extract of the present invention uses the ginkgo leaves as raw materials. Ginkgo biloba leaves are picked in autumn when they are still green, removed from impurities, and dried in the sun. The selected ginkgo leaves contain more than 0.85% of total flavonol glycosides and more than 0.25% of total terpene lactones.
[0021] The preparation method is as follows:
[0022] 1. Extraction: crush the dried ginkgo leaves to 10-20 mesh, extract several times with 65-85% ethanol, combine the extracts, filter, recover ethanol, and concentrate to a thick paste.
[0023] The influence of ginkgo leaf fineness on the extraction effect is that too fine crushing will not only increase impurities, but also affect the proposal of total flavonol glycosides and total terpene lactones. It is more suitable to use 10-20 mesh broken leaves for extraction. The particle size range of ginkgo leaves determined by the present invention is It is 10-20 mesh.
[0...
Embodiment 1
[0058] Embodiment 1: the preparation of Ginkgo biloba extract
[0059] Crush 1000g of dried ginkgo leaves to below 10-20 mesh, extract three times with 75% ethanol, add alcohol 12 times for the first time, soak for 1.0 hour, reflux extraction for 1.0 hour, add 8 and 6 times the amount for the second and third times respectively , were refluxed and extracted for 0.5 hours, the extracts were combined, filtered, ethanol was recovered under reduced pressure, concentrated to a thick paste, 500m120% ethanol was added, stirred evenly, refluxed and extracted for 0.5 hours, filtered, the precipitation was treated once again in the same way, and the filtrates were combined. Stir and add 60ml of 1% chitosan solution to flocculate, let stand, centrifuge, recover ethanol from the supernatant until it has no alcohol smell, add water to an appropriate amount, inject the sample (2ml / g) into the treated polyamide column, wash with 10% ethanol Elute, collect and elute to a set amount, then elut...
Embodiment 2
[0060] Embodiment 2: Preparation of ginkgo biloba extract sodium chloride injection
[0061] Raw material weight ratio: Ginkgo biloba extract 20g, absolute ethanol 240g (300ml), sodium chloride 900g, water for injection added to 100,000g (100,000ml).
[0062] The preparation method is as follows:
[0063] (1) Take by weighing 20g of Ginkgo biloba extract, add dehydrated alcohol 300ml to dissolve;
[0064] (2) Dilute with 10000ml of water for injection, add 900g of sodium chloride, dissolve, and adjust the pH value of the solution to 4.9 with NaOH solution.
[0065] (3) Add activated carbon (0.2% g / v) to filter and remove impurities, add water for injection to 100,000ml, stir well, measure the pH value and the content of total flavonoids and total terpene lactones, filter, and pour under local 100-level conditions Pack into 100ml / bottle, press the cap, and sterilize at 100°C for 30 minutes.
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