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Pharmaceutical compositions comprising micelles comprising lipophilic glucoiorticosteroid and only one surfactant

A technology of surfactants and compositions, applied in the field of treating mammals including human diseases, can solve problems such as instability

Inactive Publication Date: 2001-02-07
ASTRAZENECA AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Furthermore, compositions in the form of suspensions may be less stable than solutions due to phenomena such as precipitation or precipitation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0038] Preparation of micellar solutions of rofleponide palmitate

[0039] 5 g of Solutol(R) HS 15 (polyethylene glycol 660 12-hydroxystearate) manufactured by BASF in Germany was melted in a beaker at 35°C-40°C. 100 mggroleponide palmitate was added to the melt and dissolved.

[0040] An isotonic solution of 25 g of glucose in 495 g of water was heated to 35°C-40°C and added to the above melt while stirring vigorously. A clear solution containing 0.2 mg rofleponide palmitate / ml was obtained.

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PUM

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Abstract

The present invention relates to a pharmaceutical composition comprising micelles in an aqueous medium, wherein the micelles comprise a lipophilic glucocorticosteroid and one and only one pharmaceutically acceptable surfactant. The invention further relates to a process for the preparation of the pharmaceutical composition and use of the pharmaceutical composition for the manufacture of a medicament for treating allergic and / or inflammatory diseases in the respiratory tract or for treating intestinal diseases and methods for treatment of the diseases in a mammal, including man.

Description

field of invention [0001] The present invention relates to pharmaceutical compositions comprising micelles in an aqueous medium containing a lipophilic glucocorticosteroid and a single pharmaceutically acceptable surfactant. The present invention also relates to a preparation method of the pharmaceutical composition, and to the use of the pharmaceutical composition in the preparation of medicines for treating allergic and / or inflammatory diseases in the respiratory tract or for treating intestinal diseases and Methods for treating diseases in mammals, including humans. Background of the invention [0002] Rhinitis and asthma are now effectively treated with glucocorticosteroids such as mometasone furoate, budesonide, and fludisone propionate. Patent applications worth mentioning in this regard are WO 92 / 13873 and WO 96 / 19199 of Astra AB, Sweden. [0003] The most common methods of administration of glucocorticosteroids are oral and nasal inhalation. The glucocorticosteroi...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/107A61K31/56A61K31/57A61K31/573A61K31/575A61K31/58A61K47/34A61P11/00A61P29/00A61P37/08
CPCA61K31/57A61K9/1075A61P11/00A61P29/00A61P37/08A61K9/107
Inventor G·舍奎斯特
Owner ASTRAZENECA AB