Gancilorvir dispersable tablet and its preparation
A technology of ganciclovir and dispersible tablets, which is applied in the field of antiviral drug ganciclovir dispersible tablets and its preparation, can solve the problems of inconvenience for the elderly and children, the capsules can only be swallowed, the single dose is large, etc. The effect of convenient administration, short disintegration time and low production cost
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Embodiment 1
[0017] Embodiment 1 per 1000 dosage
[0018] Ganciclovir 250g
[0019] Microcrystalline Cellulose 75g
[0020] Low-substituted hydroxypropyl cellulose 25g
[0021] Polyvinylpyrrolidone (K 30 ) 5g
[0022] Lactose 40g
[0023] Magnesium Stearate 5g
[0024] Preparation:
[0025] Get the ganciclovir, microcrystalline cellulose low-substituted hydroxypropyl cellulose and lactose of the prescribed amount, sieve, mix well, and cross-linked polyvinylpyrrolidone is made into 50g / L aqueous solution, add in the above-mentioned mixture, make soft Material, passed through a 14-mesh sieve, granulated, wet granules were dried at 50-60°C for 4 hours, granulated, added with magnesium stearate, mixed evenly, and pressed into tablets.
[0026] Ganciclovir
[0027] The preparation method is the same as in Example 1, wherein polyvinylpyrrolidone is formulated into a 30 g / L aqueous solution.
[0028] Ganciclovir
[0029] The preparation method is the same as in Example...
Embodiment 4
[0030] Embodiment 4 per 1000 dosage
[0031] Ganciclovir 250g
[0032] Microcrystalline Cellulose 60g
[0033] Cross-linked polyvinylpyrrolidone 40g (plus 20g inside and outside)
[0034] Lactose 42g
[0035] Magnesium Stearate 5g
[0036] Polyvinylpyrrolidone (K 30 ) 3g
[0037] The preparation method is the same as in Example 1, wherein the polyvinylpyrrolidone is formulated into a 10 g / L ethanol solution, and a 40% ethanol aqueous solution is used as the solvent.
Embodiment 5
[0038] Embodiment 5 per 1000 dosage
[0039] Ganciclovir 250g
[0040] Microcrystalline Cellulose 86g
[0041] Cross-linked polyvinylpyrrolidone 25g
[0042] Lactose 30g
[0043] Hypromellose 4g
[0044] Magnesium Stearate 5g
[0045] The preparation method is the same as in Example 1, wherein the hypromellose is formulated into a 10 g / L aqueous solution.
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