Unlock instant, AI-driven research and patent intelligence for your innovation.

Measurement device for measuring electric signal emitted by biological sample and measurement method

A technology for measuring devices and biological samples, applied in biochemical equipment and methods, enzymology/microbiology devices, measuring devices, etc., can solve problems such as skilled technicians, and achieve the effect of high-speed and automatic electrophysiological determination of biological samples

Inactive Publication Date: 2006-12-27
PANASONIC CORP
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, there is still a problem that in order to induce cells by protruding electrodes, a technician must be skilled in operation.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Measurement device for measuring electric signal emitted by biological sample and measurement method
  • Measurement device for measuring electric signal emitted by biological sample and measurement method
  • Measurement device for measuring electric signal emitted by biological sample and measurement method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0061] figure 1 It is a schematic diagram showing the structure of the measurement device of this embodiment. figure 2 is along figure 1 Sectional view of line III-III shown.

[0062] like figure 1 As shown, the measuring device 10 of this embodiment includes: a measuring unit 11 ; a current applying unit 18 ; pumps 31 and 32 ; a measuring unit 33 ; an imaging unit 34 and a computer 35 .

[0063] The measurement unit 11 includes a substrate 17 and a substrate 16 provided on the substrate 17 . The substrate 16 and the substrate 17 are bonded to each other. like figure 1 Terminals 4a, 4b, 5a and 5b are provided on substrate 17 as shown.

[0064] like figure 1 As shown, the current applying portion 18 is electrically connected to the terminals 5 a and 5 b provided on the substrate 17 .

[0065] like figure 1 As shown, the pumps 31 and 32 are connected to the openings 13a and 14a provided on the inlet connector 13 and the outlet connector 14, respectively.

[0066] The ...

Embodiment approach 2

[0136] In this embodiment, a measurement unit 11' that can be used instead of the measurement unit 11 in the measurement device 10 of the above-mentioned first embodiment will be described with reference to the drawings. In order to simplify the description, the components common to those of the first embodiment described above are denoted by the same reference numerals.

[0137] The measurement unit 11' of the present embodiment is almost the same as the measurement unit 11 of the first embodiment described above in appearance. Therefore, in this embodiment, the figure 1 The measurement unit 11 shown will be described in place of the measurement unit 11'.

[0138] Figure 7 is along figure 1 Sectional view of line III-III shown. Figure 8 From figure 1 The perspective view of the measurement unit 11' viewed from the arrow A shown. Figure 8 The sectional view along line III-III is shown with Figure 7 quite. Moreover, in Figure 8 In , the illustration of the substra...

Embodiment approach 3

[0149] Figure 9 is a schematic configuration diagram showing the measurement device of this embodiment.

[0150] like Figure 9 As shown, the measurement device 10' of this embodiment is the same as the measurement device 10 of the above-mentioned embodiment 1 or 2, and includes a measurement unit 11 or a measurement unit 11'. In particular, in the measurement device 10' of this embodiment, a plurality of measurement units 11 or 11' are provided, and the plurality of measurement units 11 or 11' are integrated into a matrix shape. The configuration of the measurement unit 11 or 11' is completely the same as that of the above-mentioned Embodiment 1 or Embodiment 2, respectively.

[0151] The inlet connector 13 and outlet connector 14 included in each assay unit 11 or 11' are connected to a flow path converter 38 including valves and pumps. Since the inlet connector 13 is used as an outlet and the outlet connector 14 is used as an inlet by the flow path changer 38, it can be ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
diameteraaaaaaaaaa
Login to View More

Abstract

A measurement device 10 includes a measurement cell 11. The measurement cell 11 includes a substrates 17 and a substrate 16 formed on the substrate 17. The substrates 16 and 17 are bonded to each other. Thus, a flow pass 9 is formed in the measurement cell 11. As shown in FIG. 3, on the substrate 17 of the measurement cell 11, provided are a concave well 19, a protruding microelectrode 1 connected to a terminal 4a and formed on a side wall surface of the well 19, communicating tubes 15a and 15b connected to both of side surfaces of the well 19 (i.e., the flow pass 9) to face to each other, resistance baths 6a and 6b connected to the communicating tubes 15a and 15b, thin film resistors 3a and 3b arranged in the resistance baths 6a and 6b, and a reference electrode 2 connected to a terminal 4b.

Description

technical field [0001] The present invention relates to assay devices for performing electrophysiological evaluations of biological samples. Background technique [0002] Currently, in drug screening methods using biological samples (typically cells), the activity of cells is detected and the influence and action of drugs on cells are evaluated by the fluorescent dye method or the micro-pipette electrode method. [0003] The fluorochrome method is a method of optically measuring the activity of cells affected by drugs and the degree of fluorescence change accompanying changes in cell membrane potential or ion concentration by using fluorochromes that are specifically sensitive to various ion concentrations or fluorochromes that are sensitive to membrane potentials. . In the fluorochrome method, since the process of staining cells with a dye is necessary, the effect of the dye on the cells cannot be removed. Furthermore, in the fluorochrome method, since the fluorescence of...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/28G01N27/30G01N27/416G01N33/483G01N33/487
CPCB01L2300/0816B01L2200/026B01L2300/0887B01L2400/0487G01N33/48728B01L2400/0442B01L2300/0645B01L2200/0647B01L2300/14C12M1/3407B01L3/502761B01L2300/1827
Inventor 尾崎亘彦冈弘章杉原宏和
Owner PANASONIC CORP