Medicament-loaded transdermal reservoir and method for its formation

Abstract

A transdermal reservoir and a method of the present invention for loading a material into a reservoir includes providing a reservoir including a backing with an interior surface comprising a bibulous reservoir having a patient contact surface with a shape disposed on the interior surface of the backing. The method includes providing a closure sized and shaped to engage the backing for forming a releasable seal to isolate the bibulous reservoir from the ambient environment, the closure is removable from the housing to expose the patient contact surface for use. The provided closure has an inside surface with a section of an absorbent material disposed thereon. The provided section has a first surface so that when the closure is disposed on the backing, the absorbent material first surface is positioned in intimate physical contact with the reservoir. The method includes applying an aliquot of a material to the absorbent material. The method further includes placing the closure on the backing so that the first surface of said absorbent material is in intimate physical contact with the contact surface of the bibulous reservoir and the closure forms the releasable seal with the backing. The method includes allowing the reservoir- with the closure applied thereto to stand for a sufficient time to allow the aliquot of the material to be absorbed into the bibulous material thereby loading the reservoir.

Description

technical field [0001] The present invention relates to a method of loading a substance into a water-absorbing storage layer for drug administration, more particularly, a method of loading a drug into an electrode of an iontophoresis storage layer, and an iontophoresis formed by the method. storage electrode. Background technique [0002] The desired drug can be administered to the patient in ionic form by applying a voltage to the drug-loaded reservoir electrode sufficient to maintain a current flow between the drug-loaded reservoir electrode applied to the patient's skin and the return electrode (another electrode). [0003] Problems with storage stability of many iontophoresis devices reported in the literature require that the drug be stored separately from the storage layer electrodes immediately prior to use. Iontophoresis delivery of drugs is considered desirable for many drugs, but its use is not widespread because there is no single comm...

AI Technical Summary

Problems solved by technology

[0010] It is well known that many drugs are unstable under the conditions required for assembly and storage of iontophoresis reservoir electrodes

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