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Use of kaempferol-3-O-glubulariacitrin in preparing medicine for senile dementia

A rutin, senile dementia technology, which is applied in the field of medicine to achieve the effects of improving dementia symptoms, reducing cholinesterase activity, excitatory amino acid transmitters, and increasing content

Inactive Publication Date: 2007-05-23
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But so far there is no report about the effect of kaempferol-3-O-rutinoside on the prevention and treatment of senile dementia

Method used

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  • Use of kaempferol-3-O-glubulariacitrin in preparing medicine for senile dementia

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Experimental program
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Effect test

Embodiment Construction

[0009] The present invention demonstrates that kaempferol-3-O-rutinoside has the effect of preventing and treating senile dementia through the following experiments.

[0010] 1. Protective effect on learning and memory in dementia rats formed by chronic hypoperfusion (2-VO method modeling)

[0011] (See page 1061 of "Pharmacological Experimental Methodology (Third Edition)" published by People's Health Publishing House)

[0012] Learning and memory is an advanced function of the brain and an element that constitutes the highest function of the human brain—intelligence. Learning and memory impairment is one of the early symptoms of VD. Therefore, the improvement of learning and memory is regarded as a main criterion for evaluating the improvement of intelligence.

[0013] 1.1 Animals Sprague-Dawley rats, male, weighing 400-450 g, were provided by the Animal Center of the Shanghai Branch of the Chinese Academy of Sciences, and the animal certificate number is SCXK (Shanghai) 2...

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Abstract

An application of the kaempferol-3-O-rutinoside in preparing the medicine for preventing and treating senile dementia is disclosed.

Description

technical field [0001] The invention relates to the technical field of medicine, and is a new application of kaempferol-3-O-rutinoside in the preparation of drugs for preventing and treating senile dementia. Background technique [0002] Kaempferol-3-O-rutinoside (kaempferol-3-0-rutinoside), the structural formula is: [0003] [0004] Molecular formula is C 27 h 30 o 15 , is a yellow needle crystal (MeOH), with a molecular weight of 594, soluble in ethyl acetate, ethanol, and methanol. [0005] The compound can be obtained from Compositae, Carthamus tinctorius, Ginkgo biloba, Impatiens balsamina, and Acanthopanax sieboldianus. Extracted from other plants. Its preparation method is usually: safflower corolla, ginkgo leaves, impatiens flower petals, leaves of different plants of Acanthopanax, etc., are extracted by percolation with 60-80% ethanol as usual, and the extract is concentrated under reduced pressure to obtain an extract. Suspend in wa...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P25/28
Inventor 姜远英张磊郭美丽曹永兵
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY