Medicine for treating heart brain embulus disease and its preparation method
A technology of cerebral thrombosis and medicine, applied in the field of pharmaceutical composition and its preparation, can solve problems such as lack, and achieve the effects of easy quality control, reduced side effects, and small effective dose
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[0058] The preparation method can be that the two raw materials are extracted separately to obtain their respective effective parts, and then the two groups are mixed to make a composition, or the two raw materials are directly mixed to make a composition; the specific steps are:
[0059] a. Raw materials are processed into Chinese herbal decoction pieces;
[0060] b. Chinese medicine decoction pieces are placed in an extraction tank and extracted with ethanol to obtain an ethanol extract;
[0061] c. Concentrate the ethanol extract under reduced pressure until it has no ethanol smell, filter it; put it on a macroporous adsorption resin column; first elute impurities with water, and then elute with ethanol;
[0062] d. Collect the ethanol eluate, concentrate under reduced pressure, and dry under reduced pressure to obtain the final product.
[0063] In specific implementation, step b is to add 2-15 times the amount by weight, 0-95% ethanol to extract 2-4 times, each time for ...
Embodiment 1
[0074] Take 80kg of Radix Paeoniae Rubra and 20kg of Ginseng medicinal materials, crush them into coarse powder, put them into an extraction tank, add 800L of water and boil them for 3 times, 1 hour each time, filter the extract while it is hot, let it cool, and put it on D101 macroporous adsorption resin Column, fully eluted with water until the effluent is clear and free of reducing sugar reaction, then eluted with 70% ethanol, collected the 70% ethanol eluate, recovered to near dryness under reduced pressure, and dried under reduced pressure to obtain the ginseng red peony root compound Effective fraction group composition 1.9kg.
[0075] It was determined that the content of total glycosides in the composition of effective parts of the ginseng red peony compound recipe obtained in the above experiment was 63%, of which total glucosides of red paeony accounted for 86% and total saponins of ginseng accounted for 14%.
Embodiment 2
[0077] Take 80kg of Radix Paeoniae Rubra and 20kg of Ginseng medicinal materials, cut into decoction pieces, put them into an extraction tank, add 1000L of 70% ethanol to extract 3 times, each time for 1.5h, filter the extract while it is hot, let it cool, and absorb it on NKA macropores Resin column, fully eluted with water until the effluent is clear and has no reducing sugar reaction, then eluted with 70% ethanol, collected the 70% ethanol eluate, recovered under reduced pressure to nearly dry, and dried under reduced pressure to obtain Ginseng Radix Paeoniae Rubra Compound effective part group composition 1.6kg.
[0078] It has been determined that the content of total glycosides in the composition of effective parts of the ginseng red peony compound recipe obtained in the above experiment is 76%, of which total glucosides of red paeony accounts for 87% and total saponins of ginseng accounts for 13%.
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