Medication comprising nicotinic acid and tatin-like medicine
A drug and statin technology, applied in the field of drugs containing niacin and statins, can solve the problems of limited clinical application, serious liver side effects, and many adverse reactions of niacin.
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Embodiment 1
[0013] Sustained-release niacin layer prescription (dosage per tablet)
[0014] Niacin 500mg
[0015] Hypromellose (HPMC K4M ) 203mg
[0016] povidone k 30 17mg
[0017] Stearic acid 7.3mg
[0018] 70% ethanol appropriate amount
[0019] Prescription of lovastatin layer (dosage per tablet)
[0020] Lovastatin 20mg
[0021] Lactose 100mg
[0022] Starch 180mg
[0023] Stearic acid 3mg
[0024] 70% ethanol appropriate amount
[0025] Take niacin and statin and pass through a 100-mesh sieve respectively, and starch, lactose, HPMC, PVP and stearic acid pass through a 100-mesh sieve for later use. Prepare 1000 samples: Mix niacin (500g) with HPMC (203g) and PVP (17g) and pass through a 60-mesh sieve to mix evenly; add 70% ethanol, mix to prepare a soft material, pass through a 16-mesh sieve to granulate; granulate at 60°C Dry for 2 hours, take out and add stearic acid (7.3g) to mix, pass through a 18-mesh sieve and granulate to obtain niacin l...
Embodiment 2
[0027] Sustained-release niacin layer prescription (dosage per tablet)
[0028] Niacin 750mg
[0029] Hypromellose (HPMC K4M ) 210mg
[0030] povidone k 30 17.2mg
[0031] Stearic acid 7.3mg
[0032] 70% ethanol appropriate amount
[0033] Prescription of lovastatin layer (dosage per tablet)
[0034] Lovastatin 20mg
[0035] Lactose 100mg
[0036] Starch 180mg
[0037] Stearic acid 3mg
[0038] 70% ethanol appropriate amount
Embodiment 3
[0040] Sustained-release niacin layer prescription (dosage per tablet)
[0041] Niacin 1000mg
[0042] Hypromellose (HPMC K4M ) 227mg
[0043] povidone k 30 17.2mg
[0044] Stearic acid 7.3mg
[0045] 70% ethanol appropriate amount
[0046] Prescription of lovastatin layer (dosage per tablet)
[0047] Lovastatin 20mg
[0048] Lactose 100mg
[0049] Starch 180mg
[0050]Stearic acid 3mg
[0051] 70% ethanol appropriate amount
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