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Rare earth hetero poly acid salt kind antigrip virus medicine and its synthesis method

An anti-influenza virus and synthesis method technology, applied in the field of rare earth heteropoly acid salt chemical drugs and their synthesis, can solve the problems of large toxic and side effects, narrow anti-viral action spectrum, and the generation of drug-resistant strains, and achieve stable chemical properties Effect

Inactive Publication Date: 2004-05-05
NORTHEAST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, only amantadine and rimantadine are approved by the FDA for the prevention and treatment of influenza. However, due to their relatively narrow antiviral spectrum and the tendency to quickly produce drug-resistant strains, they have relatively large toxic and side effects. so that its application is limited

Method used

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  • Rare earth hetero poly acid salt kind antigrip virus medicine and its synthesis method
  • Rare earth hetero poly acid salt kind antigrip virus medicine and its synthesis method
  • Rare earth hetero poly acid salt kind antigrip virus medicine and its synthesis method

Examples

Experimental program
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Effect test

Embodiment approach 1

[0087] Dissolve 103 g (0.312 mol) of sodium tungstate dihydrate in 250 g of water, and stir to dissolve. Dissolve 27.24g (0.26mol) of germanium oxide in 2mol / L 26mL NaOH solution, dilute to 135mL and add it to the solution of sodium tungstate. The mixture was heated to 80°C, reacted for 1 h, extracted and filtered, and allowed to stand to obtain colorless crystals. The crystals were dissolved in 100ml of distilled water and 19g (0.101mol) of amantadine hydrochloride was added thereto, and stirred at 35-70°C for 1-3h to obtain a white precipitate. The precipitate was washed with a small amount of water to obtain a certain quality white solid (C 10 h 18 N) 4 [GeW 12 o 40 ]·n(H 2 O).

Embodiment approach 2

[0089] Dissolve 50 g (0.207 mol) of sodium molybdate in 200 g of distilled water, acidify with 6.0M HCl, add 3 g (0.016 mol) of amantadine amine salt into the solution, and stir at 40° C. for 1-2 h to obtain a certain amount of white solid ( C 10 h 18 N) 4 Mo 8 o 26 n(H 2 O).

Embodiment approach 3

[0091] Dissolve 100g (0.303mol) of sodium tungstate dihydrate and 10g (0.16mol) of boric acid in 500g of water. Heat at 90°C and add dropwise 3M HCL to adjust pH=6.5 under constant stirring, then add Ce(NO 3 ) 3 The solution was stirred for 30 min, and the solution was stirred with KA C Adjust the pH to 6 and continue to stir for 20 minutes, add a certain amount of alkali metal salt or amantadine salt, stir, and filter out the insoluble matter. Place at 0-5°C to get K 15 [Ce(BW 11 o 39 ) 2 ]·n(H 2 O).

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Abstract

A RE salt (or blue) of heteropoly acid (or isopoly acid) kind of 3 medicines for preventing and treating the viral influenza has the formulas: AxBy[Ln2(XM12-mO40-m)g].n(H2O) and Ap[MjOq].n(H2O). Said medicines are based on existing the viral influenza resistant medicines and prepared by chemically modifying them by organic-inorganic hybridizing.

Description

technical field [0001] The invention belongs to chemically synthesized medicines and a synthesis method thereof, and relates to rare earth heteropoly (isopoly) salt (blue) chemical medicines and a synthesis method thereof. Background technique [0002] Influenza is an acute upper respiratory infectious disease caused by influenza virus, which has the characteristics of high infectivity, rapid spread and easy occurrence of epidemics. If it is not controlled in time, it will cause serious damage to people's health. At present, only amantadine and rimantadine are approved by the FDA for the prevention and treatment of influenza. However, due to their relatively narrow spectrum of antiviral action and the tendency to quickly produce drug-resistant strains, they have relatively large toxic and side effects. So its application is limited. Therefore, chemically modifying existing anti-influenza virus drugs in order to develop high-efficiency, broad-spectrum, and low-toxic anti-in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/28A61K31/555A61P31/16
Inventor 王恩波李娟李静齐燕飞王宏芳许林吴新宇
Owner NORTHEAST NORMAL UNIVERSITY