External use pharmaceutics in simple recipe and compound recipe for treating mycosis ungualis (tinea auguium, onychomycosis)

An external preparation, a technology of onychomycosis, applied in the field of medicine, can solve the problems of difficult persistence of patients, high cost of treatment, difficult to cure, etc., and achieve the effect of not easy to relapse, high bactericidal effect and long acting time

Inactive Publication Date: 2004-08-11
李跃亨
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

They not only have a long course of treatment and high treatment costs, but also require daily application of medicine and dressing, which is troublesome and often difficult for patients to persist and cure.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Embodiment 1, butenafine hydrochloride cream:

[0010] Prescription: (1) butenafine hydrochloride 20g, (2) propylene glycol 100g, (3) 2% sodium hydroxide aqueous solution 60g, (4) white petrolatum 20g, (5) liquid paraffin 30g, (6) stearyl alcohol 40g, (7) Glyceryl monostearate 40g, (8) Propyl p-hydroxybenzoate 0.5g, (9) Menthol 5g, (10) Polyoxyl 40 stearate 40g, (11) P-hydroxybenzoate Methyl benzoate 0.5g, (12) urea 200g, (14) distilled water 444g.

[0011] Preparation method: according to the weight of the above formula, propylene glycol, 2% aqueous sodium hydroxide solution, white vaseline, liquid paraffin, stearyl alcohol, glyceryl monostearate, propyl p-hydroxybenzoate and menthol are mixed, and placed Stir in a water bath at 70°C-80°C to dissolve. Then add butenafine hydrochloride and stir to dissolve and keep the temperature at 70°C-80°C, which is the oil phase. Add polyoxyl 40 stearate, methyl p-hydroxybenzoate, and urea into distilled water to dissolve and ke...

Embodiment 2

[0012] Embodiment 2, butenafine hydrochloride coating agent:

[0013] Prescription: (1) Butenafine hydrochloride 20g, (2) Salicylic acid 50g, (3) Urea 200g, (4) Menthol 10g, (5) Glycerin 150g, (6) Ethylene glycol 300g, (7) 40g of polyvinyl alcohol-124, (8) 230g of distilled water.

[0014] Preparation method: According to the weight of the above formula, take polyvinyl alcohol-124 and add it to distilled water and glycerin to fully expand, heat it on a water bath to completely dissolve, then add urea and stir to dissolve. Then, butenafine hydrochloride, salicylic acid, menthol, and ethylene glycol were stirred and dissolved, and then slowly added to the polyvinyl alcohol-124 solution, stirred as the addition was made, and then quickly divided into packages and airtight.

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PUM

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Abstract

An externally-applied medicine for treating onychomycosis including ringworm of the nails features that it contains butenafine hydrochloride. Its advantages are high curative effect, short course of treatment, no reurrence and no toxic by-effect.

Description

Technical field [0001] The invention relates to a single and compound external preparation specially used for treating onychomycosis, which belongs to the category of medicines. Background technique [0002] For a long time, onychomycosis has attracted the attention of dermatologists due to its high incidence and difficulty in treatment. Currently, there are two routes of administration for clinical treatment: oral and external. Commonly used oral antifungal drugs are terbinafine, the course of treatment is 3-6 months; and itraconazole (Spiranox), the course of treatment is 2-4 months. They have a long course of treatment, high treatment costs, and may cause systemic adverse effects. Oral administration of these drugs to the elderly and patients with chronic liver and kidney diseases often does more harm than good. Commonly used external medicines include 8% cyclopyroneamine (Batefen), with a course of treatment of 4-12 months; and 5% amonofin (Luomele), with a course of tr...

Claims

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Application Information

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IPC IPC(8): A61K31/137A61K31/41A61K31/60A61P31/10
Inventor 李跃亨姜涛马丽芳李莉
Owner 李跃亨
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