Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A probe and fusion technology, applied in the field of probes, systems and methods for drug discovery, can solve the problems of limited usefulness and difficulty in establishing correlation, and achieve a high success rate
Inactive Publication Date: 2004-09-29
TRANSTECH PHARMA INC
View PDF0 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
Furthermore, this sequential high-throughput chemistry practice often produces larger and larger molecules whose usefulness as a starting point for optimization is limited, and additionally, a series of combinatorially derived molecules may not be easily related to each other Sex (via intuition or even computer-derived molecular descriptors)
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
preparation example Construction
[0667] 22. Preparation of resin-bonded thiouronium
[0668] 0.1 mmol of chloromethylated polystyrene resin was treated with 5 equivalents of substituted thiourea (2M dioxane / ethanol, 4:1). The mixture was heated at 90°C for 16 hours. The resin was washed with 3x ethanol (at 70°C), 3x dioxane and 3x pentane, then dried under vacuum.
[0669] 23. Formylation
[0670] 0.1 mmol of the resin-bound amine was treated with 1.0 mmol (10 equiv) of a solution of formic acetic anhydride (1M, DCM). The slurry was shaken for 16 hours, filtered, and the resin was washed successively with 3xDMF, 3xmethanol, and 3xDCM.
[0671] 24. Formation of isocyanides
[0672] 0.1 mmol resin-bound formamide with 0.5 mmol (5 equiv) TEA (1M, DCM) and 0.15 mmol (1.5 equiv) POCl 3 (1M, DCM) solution. The slurry was shaken for 16 hours, filtered, and the resin was washed successively with 3xDMF, 3xmethanol, and 3xDCM.
[0673] 25. Formation of hydrazide
[0674]0.1 mmol of the resin bound ester...
Embodiment 1
[1412]
[1413] The above compound was prepared according to the protocol of library 7, using 3-N-Boc-amino-3-(4-fluorophenyl)propionic acid as the amino acid, benzaldehyde for the reductive amination, bromoacetic acid and furfurylamine. MS (M / Z) 463.9 (M+H).
Embodiment 2
[1415]
[1416] The above compound was prepared according to the procedure of probe library 120, using n-butylamine to reductively aminate the resin, 4-N-Fmoc-amino-4-carboxy-tetrahydrothiopyran as the Fmoc-protected amino acid, and benzaldehyde as the aldehyde. MS (M / Z) 307.8 (M+H).
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
Aspects of the present invention include probes, methods, systems that have stand alone utility and may comprise features of a drug discovery system or method. The present invention also includes pharmaceutical compositions. In more detail, the present invention provides molecular probes and methods for producing molecular probes. The present invention provides also provides systems and methods for new drug discovery. An embodiment of the present invention utilizes sets of probes of the present invention and a new approach to computational chemistry in a drug discovery method having increased focus in comparison to heretofore utilized combinatorial chemistry. The present invention also provides computer software and hardware tools useful in drug discovery systems. In an embodiment of a drug discovery method of the present invention in silico methods and in biologico screening methods are both utilized to maximize the probability of success while minimizing the time and number of wet laboratory steps necessary to achieve the success.
Description
[0001] Related application statement [0002] This application claims priority to 35 USC 119 of US Provisional Application Serial No. 60 / 282,759, filed April 10, 2001, entitled "Methods of Drug Discovery," which is incorporated herein by reference. field of invention [0003] Aspects of the invention include probes, methods and systems that can be used independently, or that can incorporate features of a drug discovery system or method. The present invention also includes pharmaceutical compositions. [0004] In more detail, the present invention provides molecular probes and methods for producing molecular probes. The present invention also provides systems and methods for new drug discovery. One embodiment of the present invention uses the probe sets of the present invention and a new computational chemistry method in a drug discovery method that is gaining more and more attention compared to currently used combinatorial chemistry methods. The invention also provides comp...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more