Hericium erinaceus sulfate proteoglycan, preparation method thereof and pharmaceutical compositions with the same as active component

A technology of Hericium erinaceus sulfate and proteoglycan, which can be used in drug combinations, peptide/protein components, medical preparations containing active ingredients, etc., and can solve problems that restrict the development and utilization of Hericium erinaceus

Inactive Publication Date: 2004-11-17
高其品 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, problems such as the extraction, separation, purification method and basic chemical composition of active components in the mycelium (fruiting body) have not been resolved, and have restricted the development and development of Hericium erinaceus (fruiting body) for a long time. use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0217] Get 100g of Hericium erinaceus mycelium extract, add water to dilute, stir for 2 hours, centrifuge (3000 rpm) for 20 minutes, add ethanol to the supernatant until the alcohol concentration is 80%, centrifuge (3000 rpm) for 20 minutes, collect the precipitate, add a small amount of Dissolved in water and dried in vacuum to obtain crude polysaccharide. Add water to dissolve the crude polysaccharide, add ethanol until the alcohol concentration is 60%, centrifuge (3000 rpm) for 20 minutes, collect the precipitate, add a small amount of water to dissolve, freeze-dry to obtain.

Embodiment 2

[0219] Get 100g of Hericium erinaceus mycelium extract, add water to dilute, stir for 2 hours, centrifuge (3000 rpm) for 20 minutes, add ethanol to the supernatant until the alcohol concentration is 80%, centrifuge (3000 rpm) for 20 minutes, collect the precipitate, add a small amount of Dissolved in water and dried in vacuum to obtain crude polysaccharide. Add water to dissolve the crude polysaccharide, add ethanol until the alcohol concentration is 80%, centrifuge (3000 rpm) for 20 minutes, collect the precipitate, add a small amount of water to dissolve, freeze-dry to obtain.

Embodiment 3

[0221] Take Hericium erinaceus fruiting body 100g, wash, add 30 times the amount of water, decoct for 3 hours, filter, repeat 3 times, combine the decoction 3 times, concentrate to 800ml, add ethanol until the alcohol concentration is 80%, collect the precipitate, Vacuum dried to obtain crude polysaccharides. Take the crude polysaccharide, add appropriate amount of water to dilute, stir, add ethanol until the alcohol concentration is 60%, collect the precipitate, add a small amount of water to dissolve, freeze-dry to obtain.

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PUM

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Abstract

The invention discloses a Hericium erinaceus sulfate proteoglycan, its preparation method thereof and pharmaceutical compositions with the same as active component, whose molecular weight is 1.6í½2.6í

Description

technical field [0001] The invention discloses a sulfated proteoglycan of Hericium erinaceus, and provides a preparation method thereof and a pharmaceutical composition with the compound as an active ingredient, and belongs to the technical field of extraction methods of effective components of traditional Chinese medicine and application of extracts. Background technique [0002] The Hericium erinoceus (Bull) eers referred to in the present invention is also called Hericium erinoceus (Bull) eers, and its fruiting body has been regarded as a first-class tonic product since ancient times. Mycelium cultures have been used clinically as raw materials for many years. [0003] In the Chinese market, there is Weilexin Granule, which is made from Hericium erinaceus mycelium culture. Although the preparation shows good curative effect on stomach, duodenal ulcer, chronic gastritis, etc., long-term administration has no toxic and side effects. However, problems such as the extractio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/02A61P1/04A61P3/06A61P35/00C08B37/00
Inventor 高其品姜瑞芝杨勇杰
Owner 高其品
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