Novel virus proliferaton inhibition/virucidal method and novel pyradine nucleotide/pyradine nucleoside analogue

Abstract

In the right formula, R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ and A each have the same meaning as given in the specification. A method wherein pyrazine nucleoside analogs [2] and pyrazine nucleoside analogs [3z] are converted in vivo, and further decomposed and phosphorylated into pyrazines having virus growth inhibitory activity and/or virucidal activity Nucleotide analogs [1b]. The method can be used as a method for treating viral infection diseases. Furthermore, the pyrazinecarboxamide analogue or salt thereof of the present invention can be used as an agent for the prevention/treatment of viral infection.

Description

technical field [0001] The present invention relates to a virus growth inhibiting and / or virucidal method, characterized in that it uses pyrazine nucleotides or pyrazine nucleoside analogs or salts thereof produced by kinases; a novel pyrazine nucleotide or Pyrazine nucleoside analogs or salts thereof and a method of using them for the treatment of viral infections. Background technique [0002] Infectious viral diseases (such as influenza infection, herpes virus infection, acquired immunodeficiency syndrome (AIDS), viral hepatitis, viral hemorrhagic fever, etc.) are recognized as important medical problems and a lot of research has been done on their treatment. research, such as the use of vaccines for disease prevention or the use of medicines for treatment. Numerous nucleic acids having purine bases and pyrimidine bases and their derivatives have been developed so far as reagents for drug treatment of viral infections. The mechanism of action of these agents is that the...

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Problems solved by technology

But this compound shows no antiviral activity (no activity against sheep demyelinating encephalitis virus) [Nucleosides & Nucleotides, Vol. 15, Nos. 11 and 12, pp. 1849-1861 (1996)]

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