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Water snowflake extract, preparation and use thereof

A technology of honeysuckle extract and honeysuckle, applied in antiviral agents, drug combinations, medical preparations containing active ingredients, etc., can solve the problems of difficulty in exerting the medicinal effect of honeysuckle, low content of active ingredients, poor preparation stability, etc. To achieve the effect of stable quality, good retention rate and low irritation

Active Publication Date: 2004-12-08
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the gold and silver medicine used in preparations in the prior art has poor extraction process, which leads to low content of active ingredients in the preparation, poor preparation stability, slow action, and unstable curative effect; and it is difficult to play the role of honeysuckle. medicinal effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1. A honeysuckle extract, its preparation method is as follows:

[0045] (1) Get the honeysuckle medicinal material, add 18 times the amount of water of the medicinal material, carry out steam distillation, collect the distillate of 6 times the amount of the medicinal material, and the distillate carries out redistillation, collect the redistillate of 1.25 times the amount of the medicinal material; The filtrate is set aside, and the dregs are decocted with 10 times the amount of water for 1 hour, filtered, and the filtrates are combined;

[0046] (2) Take the above combined filtrate and use 10% Na 2 CO 3 The solution is adjusted to a pH value of 6, and put on a macroporous resin column. The amount of the resin used is twice that of the medicinal material. Elute with water for injection twice as much as the resin, discard the water eluate, and then elute with 70% ethanol on the column, collect the alcohol eluate, recover it until it has no alcohol smell, and ...

Embodiment 2

[0048] Example 2. A honeysuckle extract, its preparation method is as follows:

[0049] (1) Get the honeysuckle medicinal material, add 15 times the amount of water of the medicinal material, carry out steam distillation, collect the distillate of 4 times the amount of the medicinal material, and redistill the distillate, collect the double distilled liquid of 1 times the amount of the medicinal material; The filtrate is set aside, and the dregs are decocted with 8 times the amount of water for 1 hour, filtered, and the filtrates are combined;

[0050] (2) Take the above-mentioned combined filtrate, and use 5% Na 2 CO 3 Adjust the solution to a pH value of 5, and put it on a macroporous resin column. The amount of the resin used is 1 time that of the medicinal material. Elute with 1 times the amount of water for injection, discard the water eluate, and then elute with 60% ethanol on the column, collect the alcohol eluate, recover it until it has no alcohol smell, and obtain...

Embodiment 3

[0052] Example 3. A honeysuckle extract, its preparation method is as follows:

[0053] (1) Get the honeysuckle medicinal material, add 25 times the amount of water of the medicinal material, carry out steam distillation, collect the distillate of 8 times the amount of the medicinal material, and the distillate carries out redistillation, collect the double distilled liquid of the 2 times amount of the medicinal material; The filtrate is set aside, and the dregs are decocted with 12 times the amount of water for 2 hours, filtered, and the filtrates are combined;

[0054] (2) Take the above combined filtrate and use 15% Na 2 CO 3 Adjust the solution to a pH value of 7 and put it on a macroporous resin column. The amount of the resin used is 3 times that of the medicinal material. Collect the effluent and adjust the pH to 3 with hydrochloric acid. Elute with 3 times the amount of water for injection, discard the water eluate, and then elute with 80% ethanol on the column, col...

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PUM

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Abstract

An extract of honeysuckle flower is prepared from the honeysuckle flower through distilling twice, collecting the distilled liquid, filtering to obtain filtrate, decocting the dregs, filtering to obtain filtrate, regulating pH value, purifying by macroreticular resin column, collecting the liquid, regulating pH value, purifying by macroreticular resin column, eluting with the water for injection, rejecting the eluting liquid, eluting with alcohol, collecting the eluting liquid removing alcohol to obtain extract, and storing the distiolled liquid and extract for furture use. Its preparations prepared from said extract and their usages are also disclosed.

Description

technical field [0001] The invention relates to an extract of a Chinese herbal medicine, in particular to a honeysuckle extract and a preparation of the extract, and also relates to an application of the honeysuckle extract. Background technique [0002] The active ingredients of honeysuckle are chlorogenic acid, a small amount of flavonoids, saponins, etc., and the main medicinal ingredients are volatile ingredient linalool and water-soluble ingredient chlorogenic acid. In the prior art, honeysuckle is mainly used in compound prescriptions. However, the gold and silver medicine used in preparations in the prior art has poor extraction process, which leads to low content of active ingredients in the preparation, poor preparation stability, slow action, and unstable curative effect; and it is difficult to play the role of honeysuckle. medicinal effect. Contents of the invention [0003] The technical problem to be solved by the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P11/00A61P31/04A61P31/12
Inventor 肖伟彭国平戴翔翎凌娅王振中尚强毕宇安
Owner JIANGSU KANION PHARMA CO LTD
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