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Spray agent of dried powder in use for treating hemorrhoid and preparation method

A spray and dry powder technology, applied in pharmaceutical formulations, powder delivery, drug combination and other directions, can solve problems such as inconvenience and inconvenience, and achieve stable and reliable products.

Inactive Publication Date: 2005-06-15
KUNMING ZIJIAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Yunnan Baiyao, Yunnan Hongyao and compound Qinghao liniment all have good effects on the treatment of hemorrhoids, but they all have problems such as inconvenient use, especially in cases of bleeding and deep internal hemorrhoids.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1, the preparation of Yunnan Baiyao dry powder spray:

[0017] 1. Separation of active ingredients of Yunnan Baiyao:

[0018] Take 1 kg of Yunnan Baiyao powder, extract with 70% ethanol 8, 6, and 6 times heat reflux for 1 hour three times, combine the extracts, concentrate to 50% amount, decolorize with 0.1% solution amount of activated carbon, short (10cm) The silica gel column was used to remove impurities once, concentrated to 20% of the amount, placed overnight at 5-10°C, filtered by ultrafiltration, concentrated in vacuo to dryness, and about 70 g of effective antibacterial, hemostatic and anti-inflammatory parts of Yunnan Baiyao can be obtained (yield ~ 7%).

[0019] 2. Preparation of ultrafine powder of Yunnan Baiyao extract:

[0020] Under the condition of grade 10,000, add 50 g of the antibacterial, hemostatic and anti-inflammatory effective part of Yunnan Baiyao extracted above to 250 g of excipient chitin, grind and mix well, and carry out airflow...

Embodiment 2

[0023] Embodiment 2, the preparation of Yunnan red medicine dry powder spray

[0024] 1. Separation of active ingredients of Yunnan red medicine:

[0025] Get 1 kg of Yunnan Hongyao powder, extract with 70% ethanol 8, 6, 6 times heat reflux for 1 hour three times, combine the extracts, concentrate to 50% amount, decolorize with 0.1% active carbon of solution amount, short (10cm ) silica gel column to remove impurities once, concentrated to 20% of the amount, placed overnight at 5~10°C, filtered by ultrafiltration, concentrated to dryness in vacuum, and about 58g of effective antibacterial, hemostatic and anti-inflammatory parts of Yunnan red medicine can be obtained (yield ~ 5.8%) ).

[0026] 2. Preparation of ultrafine powder of Yunnan red medicine extract:

[0027] Under the condition of 10,000 grades, 50g of the effective part of Yunnan red medicine for antibacterial, hemostatic and anti-inflammation extracted above was added with 100g of polyacrylic acid carbomer (CP), 1...

Embodiment 3

[0030] Embodiment 3, the preparation of compound artemisia annua dry powder spray

[0031] 1. Extraction of effective parts of compound Artemisia annua:

[0032] Take 1 kg of compound Artemisia annua, powder it, extract it three times with 70% ethanol at 8, 6, and 6 times heat reflux for 1 hour, combine the extracts, concentrate to 50%, decolorize with 0.1% solution of activated carbon, short (10cm) silica gel column to remove impurities once, concentrate to 20% amount, place overnight at 5~10°C, filter by ultrafiltration, and concentrate to dryness in vacuum, about 53g of effective parts of Yunnan red medicine for antibacterial, hemostatic and anti-inflammatory can be obtained (yield ~ 5.3%).

[0033] 2. Preparation of superfine powder of compound Artemisia annua extract:

[0034] Under the condition of 10,000 grades, add 50 g of the effective part of the above-mentioned extract of compound Artemisia annua antibacterial, hemostatic and anti-inflammatory to 70 g of hypromell...

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PUM

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Abstract

A Chinese medicine in the form of powder spray for treating pile is prepared from Yunnan white (or red) medicine or compound qinghao, liniment and the filming auxiliary with high bioaffinity to mucosa. Its advantages are high curative effect and no irritation.

Description

technical field [0001] The invention relates to a medicinal preparation for hemorrhoids with hemostatic, anti-inflammatory, antibacterial and pain-relieving properties and a production method thereof. Background technique [0002] Hemorrhoids, also known as hemorrhoids and hemorrhoids, are blood vessel groups formed by enlarged and varicose venous congestion located at the lower end of the rectum, under the anal canal mucosa, and under the skin of the anus. When onset, hemorrhoids can cause discomfort such as bleeding, pain, protruding tumors, and skin tags in the anus. Sometimes hemorrhoids are also a manifestation of systemic diseases. Yunnan Baiyao, Yunnan Hongyao and compound Qinghao liniment all have a good effect on the treatment of hemorrhoids, but they all have problems such as inconvenience in use, especially in the case of bleeding and deep internal hemorrhoids. Therefore, be necessary according to the analysis to existing medicine, the research of existing medica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K9/14A61P9/14
Inventor 王京
Owner KUNMING ZIJIAN BIOTECH