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Acrylic acid base adhesive composition, and its medicinal composition and transdermal treating system

An acrylic-based, therapeutic system technology, applied in the field of transdermal therapeutic system and its preparation, can solve the problems of affecting the transdermal release of active drugs, adhesive cohesive force, decrease in shear force, easy crystallization and precipitation, etc. Loading amount and dispersion state, reducing irritation and sensitization, and expanding the effect of variety and dosage

Active Publication Date: 2005-07-20
JIANGSU KANGBEIDE PHARMA
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

[0017] 2. The amount of drug loaded is small, otherwise the active drug in the system is unstable and easy to crystallize out, thus affecting the stability of the active drug transdermal release
[0018] 3. It is easy for penetration enhancers and low-molecular plasticizers to migrate to the interface, which reduces the cohesive force and shear force of the adhesive. At the same time, the uncontrolled migration of accelerators to the interface also affects the penetration of active drugs. skin release
[0019] 4. Poor thermal stability of the system
It is prone to heat flow and cold flow, poor adhesion to the skin, stringing, edge overflow and difficult to remove when using

Method used

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  • Acrylic acid base adhesive composition, and its medicinal composition and transdermal treating system
  • Acrylic acid base adhesive composition, and its medicinal composition and transdermal treating system
  • Acrylic acid base adhesive composition, and its medicinal composition and transdermal treating system

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Embodiment Construction

[0107] The following examples illustrate the present invention, but it must be pointed out that these examples do not constitute any limitation to the scope of the present invention. Unless otherwise stated, parts, percentages and ratios in the examples are by weight.

[0108] 1. Properties of (meth)acrylate copolymers containing (meth)acrylamide or its N, N substituted monomers

[0109] The (meth)acrylate copolymer (A) containing (meth)acrylamide or its N, N substituted monomer prepared by the following polymerization process is called PSA-8-K (for comparative example, without amide function monomer), PSA-9-K, PSA-10-K, PSA-11-K, PSA-12-K, PSA-13-K, PSA-14-K, PSA-15-K, PSA-16- K.

[0110] Polymerization process: Add soft and hard monomers and an appropriate amount of solvent into the reaction tank, add the initiator (benzoyl peroxide), functional monomers, and an appropriate amount of solvent into the dropping funnel, start heating and stirring under nitrogen atmosphere, un...

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Abstract

The present invention relates to an acrylic-based adhesive composition, containing component (A) and component (B). Said component (A) contains (methyl) acrylamide or its N,N-substituted monomer (methyl) acrylate copolymer, and the component (B) contains tertiary amine or quaternary ammonium based (methyl) acrylate copolymer. Said invention also relates to application of said adhesive composition in transdermal therapeutic system, medicine composition containing said adhesive composition and transdermal therapeutic system and its preparation method.

Description

technical field [0001] The present invention relates to an acrylic-based adhesive composition and its application in a transdermal therapeutic system, and relates to a pharmaceutical composition containing the adhesive composition, a transdermal therapeutic system and a preparation method thereof. Background technique [0002] The use of transdermal therapeutic systems, such as active drug-containing pressure sensitive adhesive systems, to control the release of active drugs through the skin is well known. This transdermal therapeutic system mainly includes: polymer matrix (adhesive), active drug, accelerator and other additives. Through techniques such as dissolution (emulsification), mixing, stirring, dispersion, and molding, a transdermal therapeutic system is prepared. The transdermal treatment system is effectively adhered to the skin, so that the active drug diffuses out of the system carrier and enters the recipient's systemic circulation through the skin to produce ...

Claims

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Application Information

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IPC IPC(8): A61L24/04A61M37/00
Inventor 王树明李益农范小玲王丽薛慧勇柯光明
Owner JIANGSU KANGBEIDE PHARMA
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