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Prescription of Chinese medicine compound preparation, its preparation method and use

A technology of traditional Chinese medicine and medicine, which is applied in the field of traditional Chinese medicine composition and its preparation. It can solve the problems that the mechanism of interaction is difficult to express clearly, the pharmacological effects of each medicine are not clear, and the source of medicinal materials cannot be guaranteed, so as to improve cerebral circulation and microcirculation. , little side effects

Active Publication Date: 2005-08-10
SHANDONG QIDU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are too many medicinal flavors, complex ingredients, unclear pharmacological effects of each medicine, and difficulty in expressing the mechanism of their interaction in the above-mentioned prescriptions, which are far from the standard of modern preparations that require clear ingredients and controllable quality. , some of the medicinal materials belong to the national key protected wild medicinal species, the source of the medicinal materials cannot be guaranteed, and the cost of the product will be greatly increased when used

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] Embodiment 1: oral granule

[0098] 1. Weigh the raw materials according to the weight ratio: 400g Gastrodia elata, 250g Chuanxiong, 200g Achyranthes bidentata, 150g kudzu root; fully infiltrate with water with a weight ratio of 1:8;

[0099] 2. Extraction: Decoct twice, each time for 2 hours, control the temperature at 100°C, combine the two extracts, filter, concentrate under reduced pressure to a relative density of about 1.20 (70°C), add ethanol to the alcohol content About 50%, stir evenly, stand still at 0-4°C for 48 hours, take the supernatant, recover ethanol under reduced pressure, and concentrate to an extract with a relative density of about 1.25 (70°C);

[0100] 3. Preparation: dry the dextrin, pass through a 100-mesh sieve, and set aside; weigh 1 / 2 of the prescription amount of extract, add the prescription amount of dextrin in a conventional method, stir, mix and mix, and dry in hot air at 60°C. Pass through a 60-mesh sieve; use the remaining extract as a...

Embodiment 2

[0101] Embodiment 2: oral capsule

[0102] 1. Weigh the raw materials according to the weight ratio: Gastrodia elata 370g, Rhizoma Chuanxiong 280g, Achyranthes bidentata 200g, Pueraria radix 150g, fully infiltrate with submerged ethanol;

[0103] 2. Extraction: Heat and reflux extraction twice, each time for 2 hours, control the temperature at 60°C, combine the two extracts, filter, recover ethanol under reduced pressure, concentrate to a relative density of about 1.2 (70°C), add three times Measure the water for precipitation, stir evenly, let stand at 0-4°C for 24 hours, take the supernatant and concentrate under reduced pressure to an extract with a relative density of about 1.30 (70°C);

[0104] 3. Preparation: use the obtained extract as a binder, add appropriate amount of starch and dextrin in a conventional method, spray granulate, dry, sieve and granulate, add coating solution, and spray coat The coated granules are packed into capsule shells to obtain capsules.

Embodiment 3

[0105] Embodiment 3: oral tablet

[0106] 1. Weigh the raw materials according to the weight ratio: Gastrodia elata 430g, Rhizoma Chuanxiong 220g, Achyranthes bidentata 250g, Pueraria 100g; fully infiltrate with water with a weight ratio of 1:8;

[0107] 2. Extraction: decoct in water twice, 4 hours each time, control the temperature at 90°C, combine the two extracts, filter, concentrate under reduced pressure to a relative density of about 1.2 (70°C), add ethanol to the alcohol content About 70%, stir evenly, stand at 4°C for 48 hours, take the supernatant to recover ethanol under reduced pressure, and concentrate to an extract with a relative density of about 1.30 (70°C);

[0108] 3. Preparation: use the obtained extract as a binder, add appropriate amount of microcrystalline cellulose, sodium carboxymethyl starch, lactose, magnesium stearate, mix and granulate in a conventional way, and press it into tablets after drying, that is, Get the finished tablet.

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PUM

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Abstract

A Chinese medicine for promoting blood circulation, eliminating stasis and sputum, decreasing cholesterol, etc is prepared from gastrodia tuber, Chuan-xiong rhizome, achyranthes root and pueraria root.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and its preparation method and application, in particular to a traditional Chinese medicine composition for promoting blood circulation and removing blood stasis, quenching wind and spasm, eliminating phlegm and dredging collaterals, and lowering cholesterol and its preparation method. Background technique [0002] Stroke is a common and frequently-occurring disease among middle-aged and elderly people. It is one of the three major causes of death for the elderly. It has the characteristics of high incidence, disability, death and recurrence rate. The incidence rate in the whole country and the world is on the rise. Cardiovascular and cerebrovascular diseases have risen to the top of the cause of death. About 540,000 people in the country suffer from stroke every year. In the acute stage, there are often many sequelae left behind, such as hemiplegia, dementia, aphasia, etc. , causing g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61P3/06A61P9/10A61P11/10
Inventor 郑家晴李洁张建礼崔新德崔美兰邵义红
Owner SHANDONG QIDU PHARMA
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