Xuesaitong pharmaceutical composition and preparation method, preparation and application thereof

The technology of Xuesaitong and its composition is applied in the field of Xuesaitong pharmaceutical composition and its preparation, and can solve the problems of adverse reactions, unclearness, influence on the clinical efficacy of products, etc.

Active Publication Date: 2018-08-24
KPC PHARM INC
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Panax notoginseng saponins (PNS) is a general term for a series of saponins and their aglycon components extracted from the traditional Chinese medicine Panax notoginseng. figure out
However, the raw materials of Panax notoginseng saponins (PNS) from different manufacturers are currently on the market. Due to the different origins of the medicinal materials Panax notoginseng used for extraction of Panax notoginseng saponins, different parts of the drug, different harvesting time and years, as well as extraction methods and process conditions Different, the chemical composition of the obtained Panax notoginseng saponins (PNS) is not the same, even if it is ...

Method used

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  • Xuesaitong pharmaceutical composition and preparation method, preparation and application thereof
  • Xuesaitong pharmaceutical composition and preparation method, preparation and application thereof
  • Xuesaitong pharmaceutical composition and preparation method, preparation and application thereof

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preparation example Construction

[0181] The preparation method of Xuesaitong pharmaceutical composition of the present invention, comprises the steps:

[0182] Step 1): Weigh notoginsenoside R1, place it in an ethanol solvent, stir and dissolve to obtain solution A;

[0183] Step 2): Weigh ginsenoside Rb2, ginsenoside Rb1, ginsenoside Rg1 and ginsenoside Rc, stir and dissolve in distilled water, heat to 50-70°C, add solution A while stirring, add activated carbon for needles, heat up and boil for 30 -50 minutes, let stand to cool to room temperature, filter out activated carbon;

[0184] Step 3): Put the above filtrate in a vacuum freeze dryer, cool down to -40~-30°C, pre-freeze for 3~5 hours, then control the temperature at -25~-20°C, pressure 10~20Pa, sublimation and dry for 3~ 5 hours, and then control the temperature at 30-50°C, pressure at 1-10Pa, and analyze and dry for 4-6 hours to obtain it.

[0185] In step 1), the mass ratio of notoginseng saponin R1 to ethanol solvent is 0.05-5:100, and the volum...

Embodiment 11

[0251]The preparation of embodiment 1 1# pharmaceutical composition

[0252] Raw material composition:

[0253] Ginsenoside Rb2 54.6 g

[0254] Ginsenoside Rb1 21.1 g

[0255] Ginsenoside Rg1 11.3 g

[0256] Ginsenoside Rc 8.5 g

[0257] Notoginsenoside R1 4.5g

[0258] Total 100g

[0259] Preparation:

[0260] 1) Weigh 4.5 g of notoginseng saponin R1, place it in 100 g of ethanol solvent with a concentration of 50% by volume, stir and dissolve to obtain solution A;

[0261] 2) Weigh 54.6 g of ginsenoside Rb2, 21.1 g of ginsenoside Rb1, 11.3 g of ginsenoside Rg1 and 8.5 g of ginsenoside Rc, stir and dissolve in 900 g of distilled water, heat to 50-70°C, add solution A while stirring, Add 2.0g of activated carbon for needles, heat up and boil for 30-50 minutes, let it stand to cool to room temperature, filter out the activated carbon;

[0262] 3) Put the above filtrate in a vacuum freeze dryer, cool down to -40~-30℃ at a cooling rate of 5℃ / h, pre-freeze for 3~5 hours, ...

Embodiment 2

[0263] The preparation of embodiment 2 2# pharmaceutical composition

[0264] Raw material composition:

[0265] Ginsenoside Rb2 20.5 g

[0266] Ginsenoside Rb1 47.8 g

[0267] Ginsenoside Rg1 23.4 g

[0268] Ginsenoside Rc 6.7 g

[0269] Notoginsenoside R1 1.6 g

[0270] Total 100g

[0271] Preparation:

[0272] 1) Weigh 1.6 g of notoginseng saponin R1, place it in 100 g of ethanol solvent with a concentration of 80% by volume, stir and dissolve to obtain solution A;

[0273] 2) Weigh 20.5 g of ginsenoside Rb2, 47.8 g of ginsenoside Rb1, 23.4 g of ginsenoside Rg1 and 6.7 g of ginsenoside Rc, stir and dissolve in 950 g of distilled water, heat to 50-70°C, add solution A while stirring, Add 1.0g of activated carbon for needles, heat up and boil for 30-50 minutes, let it stand and cool to room temperature, and filter out the activated carbon;

[0274] 3) Put the above filtrate in a vacuum freeze dryer, cool down to -40~-30℃ at a cooling rate of 15℃ / h, pre-freeze for 3~...

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Abstract

The invention discloses a Xuesaitong pharmaceutical composition and a preparation method, a preparation and application thereof. The Xuesaitong pharmaceutical composition is prepared from the following components in percentage by mass: 0.001 to 99.996% of ginsenoside Rb2, 0.001 to 99.996% of ginsenoside Rb1, 0.001 to 99.996% of ginsenoside Rg1, 0.001 to 99.996% of ginsenoside Rc, and 0.001 to 99.996% of notoginsenoside R1. The Xuesaitong pharmaceutical composition and the preparation have the advantages that the obvious treatment effect on ischemic cardiovascular and cerebrovascular diseases of myocardial infarction, cerebral apoplexy, cerebral infarction, brain hemiplegia and the like, and the retinopathy or optic nerve injury disease due to ischemic cardiovascular and cerebrovascular diseases, diabetes and the like is realized, and the application prospect is broad; compared with the prior art and the product, the treatment effect is better, the safety is higher, and the requirementof clinical medicine usage can be well met; the technology of the preparation method is simple, the conditions are mild, the operation is convenient, the quality is stable and controllable, and the preparation method is suitable for industrialized large-scale production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a Xuesaitong pharmaceutical composition, a preparation method, a preparation and an application thereof. Background technique [0002] Panax Notoginseng (Burk) F. The dried roots and rhizomes of H Chen, also known as Sanqi and Tianqi, are valuable traditional Chinese medicines for treating cardiovascular and cerebrovascular diseases. "Yulan Yaojie" records that Panax notoginseng can "harmonize the blood to stop bleeding, unblock the meridian and promote blood stasis, promote blood stasis and collect new blood. All postpartum, menstrual periods, bruises, carbuncles, all blood stasis will be broken; Metrorrhagia, knife wounds, arrow wounds, all new blood will stop." [0003] Panax notoginseng saponins (PNS) is a general term for a series of saponins and their aglycon components extracted from the traditional Chinese medicine Panax notoginseng. figure it out. So far...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K9/48A61P9/00A61P9/10A61P25/02A61P27/02
CPCA61K9/4816A61K9/4825A61K31/704A61P9/00A61P9/10A61P25/02A61P27/02A61K2300/00
Inventor 周荣光赵加强顾静波文冰亭郭泽剑
Owner KPC PHARM INC
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