Medicine containing ketone effective component

A technology of active ingredients and medicines, applied in the field of medicines containing ketone active ingredients

Inactive Publication Date: 2005-08-10
谭桂山
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, beyond that, there is no literature on the use of ketones for the preparation of drugs for specific indications
It

Method used

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  • Medicine containing ketone effective component
  • Medicine containing ketone effective component
  • Medicine containing ketone effective component

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Extraction of effective parts of Swertia japonica in eastern Sichuan.

[0036] Take the dried whole herb of Swertia chinensis and heat it twice with 6 times the amount of 95% ethanol under reflux, the first time is 2 hours, and the second time is 1 hour. Concentrate the extract, adjust the pH to 8 with NaOH, and let stand at 4--8°C for 1 hour, centrifuge, take the supernatant, concentrate to 0.5 times the volume of the medicinal material, and adjust the pH to 5 with HCl. 4-- After standing at 8°C for 12 hours, it was filtered. The effective part is obtained by drying the filter residue.

[0037] After analysis and identification, the content of ketone in the extract of the effective part is 63.6% based on demethyl gentianone.

Embodiment 2

[0039] The extract of the effective part prepared above was subjected to antibacterial experiment. The results are shown in Table 1.

[0040] Table 1

[0041] Bacteria name MIC MBC

[0042] Staphylococcus aureus 0.18 0.36

[0043] Shigella dysenteriae 0.09 0.18

[0044] Escherichia coli 0.18 0.36

[0045] Salmonella typhi 0.18 0.36

[0046] Note: The unit of numbers in the table is mg / ml

Embodiment 3

[0048] According to the methods disclosed in the literature, various ketones were isolated and used in antibacterial experiments, and compared with berberine. The results are shown in Table 2.

[0049]

[0050] Note: The unit of numbers in the table is: mg / ml

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PUM

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Abstract

A medicine for antibacterial purpose and treating hypercholesterolemia and atherosclerosis is prepared from twospot swertia herb, and contains one or more of demethyl gentianone of daisy leaf, gentianone of daisy leaf, etc.

Description

technical field [0001] The invention relates to a medicine containing the active ingredient of menthone. technical background [0002] Swertia davidi Franch. is the whole herb of Swertia davidi Franch. in the family Gentianaceae. Commonly known as Shuihuanglian, Yudancao, herringcaocao, Shuilingzhi, etc., it is cold in nature and extremely bitter in taste. [0003] In the prior art, including the applicant, a series of ketones have been isolated from Swertia japonica. These ketones include [0004] Demethyl gentianone (document 1); [0005] [0006] Daisy leaf gentianone (document 1); [0007] [0008] 1,7-dihydroxy-3,8-dimethoxymenthone (Document 3); [0009] [0010] 1,8-dihydroxy-3,7-dimethoxymenthone (document 3); [0011] [0012] 1,3,8-trihydroxy-5-methoxymenthone (Document 2); [0013] [0014] 1,8-Dihydroxy-3,4,7-trimethoxymenthone (Document 3); [0015] [0016] 1,8-Dihydroxy-3-(3'-hydroxy-butoxy)menthone (Document 4). [0017] [0018]...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P9/10A61P31/04
CPCY02A50/30
Inventor 谭桂山徐康平李元建姜德建周应军
Owner 谭桂山
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