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Biomolecule analyzer

一种分析装置、生物分子的技术，应用在分析材料、测量装置、材料激发分析等方向，能够解决不能动态地测定细胞状态变化等问题

Inactive Publication Date: 2005-08-31
OLYMPUS CORP
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AI Technical Summary

Problems solved by technology

Conventional fluorescence correlation spectroscopy can capture state changes and motions of molecular groups, but cannot dynamically measure state changes at desired sites inside and outside cells, etc.

Method used

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Embodiment Construction

[0028] Hereinafter, description will be made with reference to embodiments of the present invention.

[0029] FIG. 1 is a diagram showing a basic configuration of a biomolecule analysis device according to a first embodiment of the present invention. The present invention is based on a conventional laser scanning confocal optical microscope. In the first embodiment, a laser confocal optical system is used to realize a minute measurement region. In order to form a small confocal area, an objective lens with an NA (numerical aperture) of about 1.0 is used. The confocal region thus obtained has a substantially cylindrical shape with a diameter of 0.6 μm and a length of about 2 μm.

[0030] In Fig. 1 there are two illumination systems S1a, S2a, two scanning systems S1b, S2b and two detection systems S1c, S2c. The illumination systems S1a, S2a are composed of laser light sources 1a, 1b and first lenses 2a, 2b, respectively. Scanning systems S1b, S2b are constituted by servo-typ...

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Abstract

A biomolecule analyzer of the present invention analyzes dynamic behaviors of biomolecules, and comprises image obtaining means for obtaining an image corresponding to at least one observation area of a biological sample containing biomolecules held in a measurable state, designation means for designating an arbitrary point on the image obtained by the image obtaining means, arrangement means for arranging a measuring point in a point position on the sample corresponding to the point designated by the designation means so that the measuring point may continuously coincide with the point position, measurement means for measuring a signal derived from dynamic information of an object to be measured from the measuring point arranged by the arrangement means, and analysis means for analyzing measuring results of the measurement means.

Description

technical field [0001] The present invention relates to a biomolecular analyzer for obtaining statistical properties of a plurality of specific sites in a sample, interactions among the sites, and the like. Background technique [0002] Confocal scanning optical microscopes are described in, for example, the literature "Confocal Microscopy" by T. Wilson (ed.) Academic press (London). In addition, there are "Handbook of Biological confocal Microscopy" by J.B. Pawley (ed.) Plenum Press (New York) and the like as lectures mainly focusing on biological samples. Regarding fluorescence correlation spectroscopy, there are, for example, explanations in the literature "Fluorescence correlation spectroscopy" by R. Rigler, E.S. Elson (eds.) Springer (Berlin) and the like. [0003] In the 1990s, research on single-molecule detection and imaging using fluorescence developed rapidly. For example, as a detection method of a single molecule, literature P.M.Goodwin etc. ACC.Chem.Res. (1996...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/64
CPCG01N21/6458G02B21/0076G01N21/6408
Inventor 南波昭宏石桥养亲堀川嘉明
Owner OLYMPUS CORP
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