Polygala dropping balls and preparation thereof

A technology of polygala and dripping pills, which is applied in the direction of medical formulas, medical preparations containing active ingredients, and respiratory diseases, etc. It can solve the problems of long dissolution time, low dissolution rate, inconvenient taking and carrying, and avoid gastric Effects of intestinal irritation symptoms, accelerated dissolution and absorption, and improved bioavailability

Active Publication Date: 2005-10-12
JIANGXI JIMINKEXIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Due to the preparation technology and other reasons, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicine, have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking. , thus affecting the efficacy of the drug and directly affecting the therapeutic effect
Syrup drugs also have the disadvantages of low drug content, difficulty in taking and measuring accurately, and inconvenient taking and carrying.
In addition, conventional oral dosage forms, such as syrup, capsules, etc., will produce relatively large dust pollution due to the granulation process in the preparation process, which will cause harm to the health of the staff to a certain extent, and will also pollute the environment. cause some pollution
Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0036] Now with several groups of specific examples, the preparation method of polygala dripping pills of the present invention is further described:

[0037] Group 1: Tests with a single matrix

[0038] 1. According to [Appendix: A Preparation Method of Polygala Extract], the dry powder of Polygala extract is prepared for use;

[0039] 2. Base: polyethylene glycol (1000-20000), polyoxyl 40 stearate, beta-cyclodextrin, poloxamer, sodium carboxymethyl starch, sodium lauryl sulfate, stearic acid , sodium stearate, glycerin gelatin, shellac and other pharmaceutically acceptable carriers;

[0040] 3. Proportion: take g or kg as the unit, by weight, drug extract: matrix = 1:1~1:9;

[0041] 4. Then prepare according to the process of [Preparation Method] 4-7, that is, polygala dripping pills of various specifications can be prepared.

[0042] [test results]

[0043] Test 1: In order to observe the difference in quality of Polygala dripping pills prepared when the ratio of drug e...

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PUM

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Abstract

An expectorant in the form of dripping pill is prepared from polygala root. It is based on the polygala syrup.

Description

technical field [0001] The invention relates to a pharmaceutical composition for the treatment of symptoms such as coughing up phlegm, in particular to an oral drop pill preparation of the pharmaceutical composition formulated on the basis of traditional Chinese medicine polygala syrup. Background technique [0002] According to the national drug standard WS 3 - Polygala syrup prepared according to the formula and extraction process given in B-2140-96 is an expectorant. Syrup preparations for the treatment of symptoms such as coughing up phlegm, have been clinically verified for many years, with stable quality and definite curative effect. They are commonly used pharmaceutical preparations for clinical and family use to treat the above diseases. [0003] The following is the drug standard WS 3 -The formula and extraction process of polygala syrup given in B-2140-96: [0004] Prescription: Polygala extract 200ml, concentrated ammonia solution 4ml; [0005] Preparation met...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P11/10A61P11/14
Inventor 曲韵智
Owner JIANGXI JIMINKEXIN PHARMA
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