External preparation for inhibiting keloid formation

A technology for external preparations and keloids, which is applied in the field of external preparations and can solve problems such as no one discloses it

Inactive Publication Date: 2005-10-19
TEIKOKU SEIYAKU KK TEIKOKU SEIYAKU CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] It has not been reported that the use of topical drugs containing acetylsalicylic acid or a pharmaceutically acceptable salt thereof as an active ingredient for the treatment of wounds and skin lesions can definitely inhibit keloid formation and / or hypertrophic scar formation
In addition, there is no external agent that has the above-mentioned inhibitory effect on keloid formation and / or hypertrophic scar formation while having analgesic and antipruritic effects on keloid and / or hypertrophic scar damage, and no one has disclosed it Acetylsalicylic acid or a pharmaceutically acceptable salt thereof is effective in treating the condition

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-7

[0041] Embodiment 1-7 (ointment)

[0042] According to the ingredients shown in Table 1, a base and a solvent were mixed, and then acetylsalicylic acid was added thereto. The mixture is well kneaded with stirring to obtain an ointment.

[0043] Table 1

[0044] Example

Embodiment 8

[0045] Embodiment 8 (solution)

[0046] Dissolve or disperse acetylsalicylic acid in a solvent according to the ingredients shown in Table 2, and quickly add the mixture under stirring to the heated purified water to which the other ingredients have been added, and continue stirring the resulting mixture until it becomes completely homogeneous liquid to obtain a solution.

[0047] Table 2

[0048] Example

Embodiment 9 and 10

[0049] Examples 9 and 10 (gels)

[0050] According to the ingredients listed in Table 3, after the aqueous polymer compound is dissolved by heating, acetylsalicylic acid is dispersed or dissolved in a solvent, and the resulting mixture is kneaded with the remaining matrix until it becomes uniform to obtain the desired gel.

[0051] table 3

[0052] Example

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PUM

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Abstract

An external preparation which contains acetylsalicylic acid or its salt as an active ingredient and has an effect of inhibiting keloid and / or hypertrophic scar formation as well as an analgesic and antipruritic effect.

Description

technical field [0001] The present invention relates to an external preparation having an effect of inhibiting the formation of keloids and / or hypertrophic scars (scarring) and having an analgesic and antipruritic effect on an affected site. [0002] Specifically, the external preparations involved in the present invention contain acetylsalicylic acid or a pharmaceutical salt thereof as an active ingredient, and have an excellent effect of inhibiting the formation of keloids and / or hypertrophic scars and have an effect on the site of action. Analgesic and antipruritic effect, the present invention also relates to a topical treatment device using the external preparation. Background technique [0003] Until now, in the treatment of keloids with drugs, methods of applying steroids or injecting steroids into keloid lesions have been used. However, the former did not produce any definite curative effect, while the latter, though effective, required dozens of repeated injections...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/616A61P17/02A61P17/04
CPCA61K31/616A61P17/02A61P17/04
Inventor 川添刚铃木茂彦稻本千子川田光裕
Owner TEIKOKU SEIYAKU KK TEIKOKU SEIYAKU CO LTD
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