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Vein injection medicine for compound salvia root and ligusticum and its preparation method

A technology of Chuanxiong and Ligusticum, which is applied in the field of salvia miltiorrhiza and Chuanxiong compound intravenous injection medicine and its preparation, which can solve the problems of unstable quality and affecting curative effect, and achieve the effects of improving microcirculation, easy transportation and storage, and good application prospects

Inactive Publication Date: 2005-10-26
昆明法莫泰克药物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a medicine with good stability of active ingredients and good curative effect for the existing Danshen Chuanxiong Compound Injection such as Guanxinning Injection which only has small water injection dosage form, unstable quality, easy to use, and affects the curative effect. Significant Dan Shen participated in the dosage form of Chuanxiong compound intravenous injection to improve the quality of drugs and facilitate clinical application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Take 2kg each of Salvia miltiorrhiza and Chuanxiong, decoct three times with water, 2 hours for the first time, 1.5 hours each for the second and third times, combine the decoctions, filter, concentrate the filtrate to about 2000ml, and use ethanol precipitation for the second time, the first time Make the alcohol content reach 75%, and the second time is 85%. After adding ethanol each time, place it in cold storage, filter, combine the filtrate, concentrate to about 700ml, dilute to 4000ml with water for injection, and adjust the pH value to 3.2 with dilute hydrochloric acid , refrigerate, filter, adjust the pH value to 6.8 with 10% sodium hydroxide solution, concentrate to 1000ml, refrigerate, filter, then adjust the pH value to 6.8, boil for 30 minutes, add 0.2% activated carbon, cool slightly, filter, The filtrate was adjusted to a pH value of 6.8, added with an appropriate amount of mannitol and water for injection to make 1000 ml, sterilized by filter membrane, fil...

Embodiment 2

[0017] Preparation of Salvia miltiorrhiza extract: Take 10 kg of Salvia miltiorrhiza, add water and decoct three times, the first time for 2 hours, the second and third times for 1.5 hours each, combine the decoction, filter, and the filtrate is concentrated to about 5000ml, which is the crude extract of Danshen (also known as Danshen crude extract). It can be dried into solid); the crude extract of Salvia miltiorrhiza is dissolved and diluted with appropriate amount of water, and is treated twice with ethanol precipitation, the first time the alcohol content reaches 75%, the second time it is 85%, and each time after adding ethanol, it is refrigerated , filtered, combined filtrate, concentrated to about 1750ml, which is the refined extract of Salvia miltiorrhiza (also can be dried into solid); the refined extract is dealcoholized, according to the amount of the column sample (equivalent to medicinal material) and the amount of wet resin (1:8 / W:V) ratio, carry out polyamide co...

Embodiment 3

[0020]Take the crude extract as raw material, take 1000ml each of the two crude extracts according to the amount of medicinal materials, stir and mix evenly, and use ethanol precipitation for two times, the first time the alcohol content reaches 75%, and the second time it is 85%. After adding ethanol each time, put them in cold storage, filter, combine the filtrates, concentrate, dilute about 6 times with water for injection, adjust the pH value to 3.2 with dilute acid, refrigerate, filter, adjust the pH value to 6.8 with dilute alkaline solution, concentrate, Refrigerate the concentrated solution, filter, then adjust the pH value to 6.8, boil for 30 minutes, add 0.2% activated carbon or use hollow fiber membrane ultrafiltration technology to remove impurities, cool slightly, filter, adjust the pH value of the filtrate to 6.8, add appropriate amount of frozen Dry auxiliary agent and water for injection to 1000ml, sterilized, subpackaged, freeze-dried to make 400 bottles of pow...

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Abstract

A Chinese medicine for intravenous injection is prepared from red sage root and Chuan-xiogn rhizome through extracting by decocting, depositing in alcohol, ultrafiltering, adding freeze-drying additive and freeze drying.

Description

technical field [0001] The invention belongs to the technical field of medicines, and relates to a compound intravenous injection medicine of salvia miltiorrhiza and chuanxiong for treating cardiovascular and cerebrovascular diseases and a preparation method thereof. Background technique [0002] Salvia miltiorrhiza and Chuanxiong are commonly used drugs in traditional Chinese medicine with the function of promoting blood circulation and removing blood stasis, and have a long history of clinical application. Ligusticum chuanxiong mainly contains ferulic acid, ligustrazine and other ingredients. The chemical composition of Danshen is mainly divided into two parts: water-soluble components and fat-soluble components. Its fat-soluble components mainly include tanshinone I, II, isotanshinone, etc.; water-soluble components mainly include salvianolic acid compounds such as: salvianolic acid A, salvianolic acid B, danshensu, protocatechualdehyde, etc., among which salvianolic aci...

Claims

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Application Information

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Patent Type & Authority Applications(China)
Inventor 王立新
Owner 昆明法莫泰克药物技术有限公司
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