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Nanometer vauqueline liposome transdermal spray agent, its preparation method and application thereof

A technology of strychnine lipid and plastid, which is applied in the field of strychnine preparation, can solve the problems of inconvenient storage and transportation of nanometer strychnine liposome suspension, and achieves remarkable curative effect, good permeability and absorption. high rate effect

Inactive Publication Date: 2005-11-23
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the nano strychnine liposome suspension is extremely inconvenient to store and transport

Method used

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  • Nanometer vauqueline liposome transdermal spray agent, its preparation method and application thereof
  • Nanometer vauqueline liposome transdermal spray agent, its preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Preparation of suspension aqueous solution containing nano strychnine liposomes:

[0037] Weigh 60mg of strychnine, 450mg of hydrogenated lecithin and 150mg of cholesterol and dissolve them in 20ml of chloroform, transfer them to a round-bottomed flask, and at a water bath temperature of 40°C at a speed of 150r / min, evaporate the organic solvent under reduced pressure to form a film , dried under vacuum at room temperature for 12 hours. Then add 20ml of Tween 80 aqueous solution with a concentration of 9mg / ml and 40ml of phosphate buffer saline, fully swell for half an hour, then sonicate in a water bath for 10min, and then use an ultrasonic cell pulverizer to sonicate at a certain power for 20min to obtain a whitish Opalescent strychnine liposome, wherein the content of strychnine is 1 mg / ml, and the content of strychnine liposome is 11 mg / ml. The liposome particle size is 200nm.

[0038] Ultrasonic cell pulverizer is a general-purpose equipment, such as the model JY...

Embodiment 2

[0040] Preparation of nano strychnine liposome lyophilized powder:

[0041] Add 40 mg of taurine borneol and 40 mg of glucose to the suspension of nano strychnine liposomes containing 11 mg / ml strychnine liposomes in 60 ml, put the above mixed solution in a vacuum freeze dryer at -50 Dry at ℃ for 24 hours to obtain the freeze-dried powder of nano strychnine liposome. The powder has stable performance, is convenient for long-term storage, is convenient for transportation, and is easy to disperse in physiological saline.

Embodiment 3

[0043] Preparation of nano strychnine liposome lyophilized powder:

[0044]Add 50 mg of azone and 40 mg of mannitol to the suspension of nano-strychnine liposomes containing 11 mg / ml strychnine liposomes in 60 ml, put the above mixed solution in a vacuum freeze dryer at -40 Dry at ℃ for 20 hours to obtain the freeze-dried powder of nano strychnine liposome. The powder has stable performance, is convenient for long-term storage, is convenient for transportation, and is easy to disperse in physiological saline.

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Abstract

The invention discloses a nanometer vauqueline liposome transdermal spray agent, its preparation method and application, wherein the preparation is prepared through mixing nano strychnine liposome freeze-drying powder containing a predetermined of transdermal promoting agent and freeze-drying protecting agent with physiological saline by a predetermined proportion. The prepared preparation is a nano liposome with dispersed constituents and good stability. It can be used for the treatment for various diseases including gout, arthritis and traumatic injury.

Description

technical field [0001] The invention relates to a strychnine preparation, in particular to a transdermal preparation of nano-strychnine liposome containing a transdermal accelerator and a freeze-drying protective agent. Background technique [0002] Strychnium is a perennial plant belonging to the Strychraceae. According to literature reports (Miao Xinrong et al. The general situation of the clinical application of Nuxebra, Xinjiang Traditional Chinese Medicine, 2000, 18 (2): 61), Nuxyche has outstanding effects such as dispelling stagnation and detumescence, dredging collaterals and relieving pain, clinically It is effective in treating various painful diseases such as gout, arthritis, bruises, etc. But at the same time, the clinical use of Nuxebra chinensis is restricted by various factors, mainly as follows: (1) It is highly toxic and belongs to the state-controlled drug, and its toxic reactions are mainly manifested in the central nervous system, respiratory system, and...

Claims

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Application Information

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IPC IPC(8): A61K31/475
Inventor 刘昌胜袁媛杨柏灿
Owner EAST CHINA UNIV OF SCI & TECH
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