Antibiotic composition

A composition and technology of antibiotics, applied in the field of third-generation cephalosporins, can solve the problems such as the increase of enzyme-producing drug-resistant bacteria and the decline of curative effect.

Inactive Publication Date: 2005-12-21
黄文豪
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cefmenoxime is a broad-spectrum antibiotic. Due to its own shortcomings, cefmenoxime has only been used as a single-component drug so far. However, with the wide application of clinical antibiotics, the number of enzyme-producing and drug-resistant bacteria continues to increase, and the curative effect is also decreasing. drop with it

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] The minimum inhibitory concentration (MIC) of cefmenoxime hydrochloride, potassium clavulanate, sulbactam and tazobactam to the bacteria used in the experimental example, the results are shown in Table 1

[0008]

bacteria

Cefmenoxime Hydrochloride

(μg / ml)

Sulbactam

(μg / ml)

Tazobactam

(μg / ml)

Potassium clavulanate

(μg / ml)

Number of plants

Mic 90

Number of plants

Mic 90

Number of plants

Mic 90

Number of plants

Mic 90

Escherichia coli

39

0.10

30

64

30

＞128

30

32

Klebsiella pneumoniae

36

0.20

16

64

16

＞128

16

32

Staphylococcus aureus

27

6.00

12

64

12

64

12

＞128

Pseudomonas aeruginosa

34

32

30

64

30

＞128

30

＞128

Acinetobacter

13

＞128

12

32...

Embodiment 2

[0012] (1) Get 50g of cefmenoxime hydrochloride and 50g of sulbactam and mix, add 8g of sodium carbonate co-solvent in the process, operate according to known powder injection preparation process procedure, make the sample for experiment.

[0013] According to the above method, cefmenoxime hydrochloride and sulbactam, cefmenoxime hydrochloride and tazobactam, cefmenoxime hydrochloride and potassium clavulanate experimental samples can also be obtained. The experimental results are shown in Table 2

[0014]

bacteria

Cefmenoxime Hydrochloride / Sulbactam

(μg / ml)

Cefmenoxime Hydrochloride / Tazobactam

(μg / ml)

Cefmenoxime Hydrochloride / Potassium Clavulanate

(μg / ml)

Number of plants

Mic 90

Number of plants

Mic 90

Number of plants

Mic 90

Escherichia coli

22

＜0.10

12

＜0.10

16

＜0.10

Klebsiella pneumoniae

12

＜0.20

8

＜0.20

10

＜0.20 ...

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PUM

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Abstract

The present invention discloses an antibiotic composition. It includes the following components: cefmenoxime or cefmenoxime salt or hydrate of cefmenoxime salt or cefmenoxime ester or precursor medicine of cefmenoxime as active component, and beta-lactamase inhibitor as inhibitor; the described beta-lactamase inhibitor is clavulanic acid or sulbactam or tazobactam or clavulanic acid medicinal salt or its hydrate or precursor medicine of clavulanic acid or sulbactam medicinal salt or its hydrate or tazobactam medicinal salt or its hydrate or tazobactam ester or precursor medicine of tazobactam. The mixing ratio of both cefmenoxime and inhibitor (by weight portion) is 1:0.1-99.

Description

(1) Technical field: [0001] The present invention relates to third generation cephalosporins, especially antibiotic compositions. (two) background technology: [0002] Cefmenoxime (Cefmenoxime) is a third-generation cephalosporin antibiotic, which has obvious antibacterial effects on Escherichia coli, Klebsiella pneumoniae, Citrobacter, Proteus mirabilis, Salmonella, and Shigella; Enterobacter aerogenes and Enterobacter agglomerates also have good antibacterial activity; antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, Listeria, and Streptococcus faecalis is relatively low; Amidase and cephalosporinase are particularly stable and extended-spectrum β-lactam TEM enzymes resistant to enzyme inhibitors are stable but hydrolyzed by Acinetobacter and Bacteroides fragilis. Cefmenoxime is a broad-spectrum antibiotic. Due to its own shortcomings, cefmenoxime has only been used as a single-component drug so far. However, with the wide application of clini...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/546
Inventor 黄文豪
Owner 黄文豪
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