Plant extract with blood sugar lowering activity and its use

A technology of plant extracts and blood sugar, applied in the field of biomedicine, has achieved broad development prospects, rich resources and far-reaching effects

Inactive Publication Date: 2006-01-04
珍奥集团股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, most western medicines have certain side effects, such as allergic reactions, anorexia, nausea, vomiting, abdominal distension, diarrhea and other gastrointestinal reactions and lactic acidosis

Method used

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  • Plant extract with blood sugar lowering activity and its use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Take 50 g of the dried leaves of the Chinese planted Yalong fruit (Smallanthus sonchifolius Poepp. & Endl.) and boil it with 1000 ml of distilled water for 20 minutes to obtain a water extract with a concentration of 5%. The water extract was filtered twice with Xinhua filter paper, and the filtrate was subjected to animal experiments. Rats are induced as a diabetes model [document 2. H.G. Vogel [German] et al., edited, Du Guanhua et al. Pharmacological experiment guide-new drug discovery and pharmacological evaluation. Beijing: Science Press, 2001. It describes the experimental methods for establishing an induced diabetes animal model and testing its pharmacological activity. ](Fasting blood glucose>200mg / dl) After the rats, they were divided into two groups, each with eight animals, the blank control group (fasting blood glucose was 313±74mg / dl) free drinking water, the experimental group (fasting blood glucose was 295±124mg / dl) ) Drink the water extract of Yacon leaves f...

Embodiment 2

[0023] Take 20g of Chinese planted Yacon (Smallanthus sonchifolius Poepp. & Endl.) dry leaves, boil it with 100ml of distilled water, and extract for 30 minutes to obtain a water extract with a concentration of 20%. The water extract was filtered through a 0.2μm membrane to sterilize, and the filtrate was subjected to animal experiments. The experimental animals were rats induced to be diabetes models (fasting blood glucose>200mg / dl) and were divided into two groups. The blank control group was intraperitoneally injected with distilled water, and the experimental group was injected with 20% water extract at a dose of 4ml / kg rat body weight. After administration, the fasting blood glucose of the two groups was measured, and it was observed that after 24 hours, it had a significant effect of reducing the blood glucose of diabetic rats induced by STZ (P<0.05, compared with the blank group).

Embodiment 3

[0025] Take 30g of the Chinese planted Yalong fruit (Smallanthus sonchifolius Poepp. & Endl.) dry leaves, boil it with 3000ml of water for 5 hours. The water extract was filtered twice with Xinhua filter paper, and the filtrate was subjected to animal experiments. The experimental process is the same as in Example 1. After 7 days, the blood glucose of the rat began to drop (fasting blood glucose is 266±103 mg / dl), and after 9 days, the blood glucose of the rat dropped to the lowest (fasting blood glucose of 150±60 mg / dl), during 12-30 days The blood sugar of the experimental group tended to be stable. Therefore, the experiment proved that the water extract of 1% Yacon leaves has the effect of lowering the blood sugar of diabetic rats induced by STZ.

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Abstract

The present invention relates to biomedicine technology, and is especially one kind of pant extract with blood sugar lowering activity and its application. The preparation process includes reflux extraction of yacon leaf in water solution of methanol, ethanol or acetone, and recovery of solvent; or decoction of yacon leaf in water to obtain the pant extract with blood sugar lowering activity. The present invention has the advantages of high bioavailability, obvious blood sugar lowering effect, no toxic side effect, etc.

Description

Technical field [0001] The invention relates to biomedicine, in particular to a plant extract with the activity of lowering blood sugar and its application. Background technique [0002] Diabetes is a common and frequently-occurring disease among middle-aged and elderly people, and its incidence is about 3% to 5%. At present, with the improvement of people’s living standards, the incidence of diabetes is also increasing. The World Health Organization has listed it as the world’s three most difficult diseases along with tumors and cardiovascular and cerebrovascular diseases. It is estimated that there are about 70 Millions of people have new diabetes. Because diabetes can also cause other acute or chronic complications, diabetes has become one of the chronic diseases that seriously affect people's health; therefore, it is imminent to actively prevent and treat diabetes. [0003] At present, western medicine is the modern drug treatment for diabetes. Type I diabetes can only be con...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/18A61K9/20A61K9/14A61K9/06A61K9/16A61K9/08A61K9/10A61P3/10
Inventor 谭成玉胡建恩杜昱光王焕弟白雪芳
Owner 珍奥集团股份有限公司
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