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Slow release implantation system for injectable calcium sulphate based medication

A calcium sulfate-based, calcium sulfate hemihydrate technology, applied in the field of biomedicine, can solve the problems of repeated infection, limit the release of antibiotics, limit the application, etc., and achieve the effects of overcoming loose contact, preventing wrapping, and stabilizing the local release rate

Inactive Publication Date: 2006-02-01
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, only 25% of the gentamicin in Septopal can be released; in addition, the chain beads are easily surrounded by fibrous connective tissue, which further limits the release of antibiotics, so that the local antibiotic concentration cannot be achieved.
Since the PMMA chain beads cannot be degraded, the second operation will incise the beads, but this operation will bring great pain to the patient. After the chain is pulled out, there will be residual bone defects, and it is easy to form sinus tracts and dead spaces, which will lead to repeated infections.
Due to the above deficiencies, its clinical application is limited.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0025] Take 100 parts of calcium sulfate hemihydrate, add 10 parts of vancomycin, 3 parts of calcium phosphate, 2 parts of hydroxypropyl methylcellulose and 0.4 parts of glyceryl stearate, mix well, and put it into a medicine bottle Sterilized with Co-60 to obtain component A. Component B is saline. When in use, mix 60 parts of component B and component A thoroughly, and inject to the desired site with a syringe. The vancomycin mentioned above can be replaced by other antibiotics such as leucomycin, gentamicin, tobramycin or cefuroxime.

example 2

[0027] Take 100 parts of calcium sulfate hemihydrate, add 1 part of bone morphogenetic protein, 3 parts of calcium carbonate, 1 part of alginate and 1 part of polyethylene glycol, mix well, put it into a medicine bottle and use Co-60 Sterilize to obtain Component A. Component B is saline. When using, mix 50 parts of component B and component A thoroughly, and inject it to the desired site with a syringe.

example 3

[0029] Take 100 parts of calcium sulfate hemihydrate, add 5 parts of doxorubicin, 3 parts of calcium sulfate dihydrate, 3 parts of gelatin and 0.2 parts of sodium dodecylsulfonate, mix well, put it into a medicine bottle for use Co-60 sterilization to obtain Component A. Component B is saline. When using, mix 30 parts of component B and component A thoroughly, and inject it to the desired site with a syringe. The above doxorubicin can be replaced by cisplatin, melphalan, carmustine, camptothecin or paclitaxel.

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PUM

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Abstract

A slow-release calcium sulfate-based medicine able to be implanted in human body by injection for treating the dysostosis caused by osteomyelitis and bone cancer is composed of the component A prepared from semi-hydrated calcium sulfate, nucleator, plasticizer, surfactant and medicine and the component B which is a diluent. Before application the components A and B are mixed and then the mixture in the form of paste is injected to the focus position and shaped.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, in particular to an injectable calcium sulfate-based drug slow-release implant system. Background technique [0002] Chronic osteomyelitis is difficult to treat due to the formation of dead space and sequestrum, and complete lesion debridement supplemented by local application of antibiotics is considered to be an effective method. Since the successful development of gentamicin-PMMA bead chain (Septopal) in 1978 and its application in the treatment of osteomyelitis, this implant-type sustained-release body has been popularized and used in Europe. Septopal has the characteristics of low toxicity and long drug effect, and is often used in plastic surgery and osteomyelitis. [0003] However, only 25% of the gentamicin in Septopal can be released; in addition, the chain beads are easily surrounded by fibrous connective tissue, which further limits the release of an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/02A61M31/00
Inventor 高建平刘宇霍书娟王晓东
Owner TIANJIN UNIV
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